Analysis OF Rat Skin Mast Cell’s Function under Chronic Inflammation

Mukhlynina E.A.

Institute of Immunology and Physiology, UB of RAS; Ural Federal University, Yekaterinburg, Russian Federation

Abstract. A study of skin mast cell functional activity in cotton pellet-induced chronic inflammation has been provided. The data suggest that the general mast cell reaction to the impact is their migration from places of formation and deposition to the skin. Chronic inflammation also causes the activation of mast cell heparin secretion in inflammation focus and in the skin away from granuloma, which is accompanied by an increase of granulolysis. Out research data support the hypothesis of the universality of the mast cell population response to impact of various kinds.

Keywords: mast cell, chronic inflammation, skin

REFERENCES
1. Mukhlynina, E.A. The reaction of the connective tissue of various organs of rats to acute local inflammation. Е.А. Mukhlynina, B.G. Yushkov. Izvestija Komi nauchnogo centra UrO RAN. – 2013. – V. 14, №2. – P. 42–49.
2. Artashyan, O.S. Study of the functional activity of mast cells during immobilization stress. O.S. Artashyan, B.G. Yushkov, E.A. Mukhlynina. Tsitologyia. — 2006. Vol. 48, no. 8. pp. 665-668.
3. Mukhlynina, E.A. Reaction of fibrous connective tissue under the action of extreme factors on the body: authoref. dis. … cand. biol. sciences: 03.03.01. Mukhlynina Elena Arturovna. – Ekaterinburg, 2013. – 24 p.
4. Artashyan, O.S. System of mast cells under the action of extreme factors on the organism (experimental study): authoref. dis. … cand. biol. sciences: 03.00.13. Artashyan Olga Sergeevna. – Ekaterinburg, 2006. – 23 p.
5. Winter, C.A. Effect of alterations in the side chain upon antiinflammatory and liver glycogen activities of hydrocortisone esters. C.A. Winter, C.C. Porter. J. Am. Pharm. Assoc. Sci. Educ. – 1957. – Vol. 46, Is.9. pp. 515–519.

Authors
Mukhlynina Elena A.
Institute of Immunology and Physiology, UB of RAS; Ural Federal University
PhD, scientific associate
Russian Federation, 620049, Ekaterinburg, Pervomayskaya st., 106
elena.mukhlynina@yandex.ru

 
 
 

Authorization