Effects of Psychogenic Stress on the Reproductive Function in Male Rats

Experimental and clinical research works

Makutina V.A., Balezin S.L., Rosliy O.F., Mamina V.P., Pashnina I.A.

Abstract.
The arm of this work was to evaluate the effect of sub-chronic stress on reproductive function in male rats. Rats underwent sub-chronic stress by immobilization on the plate for 30 minutes twice a week for spermatogenic cycle (days 48–52). Degenerative processes in the testis, the apoptosis of seminiferous tubules, aberrant divisions of germ cells in seminiferous epithelium, necrosis spermatozoa, and the number of spermatozoa with DNA fragmentation were significantly increased by stress. Also, there were a trend to a change in the production of testosterone and an increase in pre-implantation loss. Content in the testis of different types of germ cells, Leydig and Sertoli cells, as well as sperm motility and sperm morphology did not change by stress.

Key words:
stress, reproductive system, subfertility.

Authors:
Makutina Valery A.
The Federal Budgetary Institution of Science «Ekaterinburg Medical Research Center of Preventive Medicine and Health Protection of Workers of Industrial Enterprises», Ekaterinburg, Russia,Closed joint¬stock company «Family Medicine Centre», Ekaterinburg, Russia

Rosliy Oleg F., MD
The Federal Budgetary Institution of Science Ekaterinburg Medical Research Center of Preventive Medicine and Health Protection of Workers of Industrial Enterprises, Ekaterinburg, Russia

Balezin Sergey L., PhD
Closed joint¬stock company «Family Medicine Centre», Ekaterinburg, Russia

Mamina Vera P.
The State Federal Budgetary Institution of Science «Institute of Plant and Animal Ecology», Ekaterinburg, Russia

Pashnina Irina A.
The State Institution of Health Sverdlovsk Region «Regional Children's Hospital», Ekaterinburg, Russia
1/3, Nachdiva Vasileva Str., Ekaterinburg, Russia
e-mail: Makutina_v@rambler.ru