Features of Change of System of a Hemostasis at Patients with a Inherited Thrombophilia in In Vitro Fertilization Protocols

Experimental and clinical research works

Mayasina E.N., Oboskalova T.A.

Abstract.
Authors carried out the retrospective analysis of changes of parameters of system of a hemostasis at superovulation stimulation in protocols of invitro fertilization at 132 patients with a congenital trombofiliya. Women are divided into three groups depending on number of the received oocytes (to the 4th, from 5 to 9, more than 10), also the group of the control, those patients to whom hormonal stimulation wasn't carried out is included in research. The condition of a hemostasis is estimated on 5 parameters: APTT, MNO, PV, fibrinogen, D-dimer. Change of all parameters of system of a hemostasis towards hypercoagulative was established, the most expressed condensation of blood was observed after carrying out a puncture of follicles and transfer of embryos in a uterus cavity. That the risk of hyper coagulation is probable when receiving 5 oocytes and more is also defined. Authors drew a conclusion on need of purpose of a preventive dose of low-molecular heparins for the purpose of prevention of tromboembolic complications after receiving 5 and more oocytes as a result of superovulation stimulation.

Key words:
in vitro fertilization, mutations of genes of system of a hemostasis, ovarian hyperstimulation syndrom, low molecular weight heparins.

Authors:
Mayasina Elena N. 
e-mail: elena.mayasina@gmail.com

Oboskalova Tatiana A.
MD, professor

«Сentre of Family Medicine», Ekaterinburg, Russia
GBOU VPO UGMA, obstetrics and gynecology chair, Ekaterinburg, Russia
1/3, N. Vasilyeva Str., Ekaterinburg, Russia