Clinical Dynamics, Laboratory Results and Infarct Volume after Single Subcutaneous Granulocyte Colony-Stimulating Factor Injection in Patients with Acute Ischemic Stroke

Clinical Experience

Alasheev A.M., Belkin A.A., Leiderman I.N., Rogov D.Yu.,

Isakova T.M., Fechina L.G., Ivanov R.A., Leont’ev S.L.

Abstract.

The present study of safety of granulocyte colony-stimulating factor (G-CSF) as a neuroprotector involved 9 adult patients with unilateral ischemic stroke in the carotid region presenting within 48 hours of onset. All patients received subcutaneous G-CSF injections in the dose of 10 mkg/kg. Safety was evaluated by mortality, frequency of hemorrhagic transformation of infarction and adverse events. G-CSF injections significantly increased the level of CD34-positive cells in peripheral blood.

At 90 days positive dynamics in the need for third-party assistance and in other studied characteristics was shown. Single daily bone marrow stimulation by G-CSF in the dose of 10 mkg/kg is appeared to be safe.

Key words:

ischemic stroke, stem cells, granulocyte colony-stimulating factor, clinical study.

Authors:

Alasheev Andrey M.

Sverdlovsk regional hospital №1, Ekaterinburg, Russia

Belkin Andrey A;

Sverdlovsk regional hospital №1», Institute Medical Cell Technologies,Ekaterinburg,Russia

Leiderman Ilya N

Institute Medical Cell Technologies; Clinical Institute of the Brain, Ekaterinburg, Russia

Rogov Dmitry Yu

City hospital №40», Ekaterinburg, Russia

Isakova Tatyana M.

City hospital №40», Ekaterinburg, Russia

Fechina Larisa G.

City hospital №40», Ekaterinburg, Russia

Ivanov Roman A.

City hospital №40», Ekaterinburg, Russia

Leont’ev Serey L.

Institute Medical Cell Technologies, Ekaterinburg, Russia

620135, Russia, Ekaterinburg, street Hotbed, д.8, sq. 102

alasheev@live.ru