Electron-Conformational Theory of Ryanodine Channels Functioning in Sinoatrial Node Cells

The general pathology and pathological physiology

Ryvkin A.M.

Abstract.
Within the framework of the previously proposed Electron-Conformational model of RyR-channels a numerical model of the stochastic dynamics of calcium release unit in heart cells was developed. It was shown that the isolated from the membrane «clock» a release unit in pacemaker cells can act as a self-sustaining oscillator with fluctuations of the frequency and amplitude of the Ca2+ concentration oscillations.

Key words:
Calcium “clock”, Sinoatrial node cells, autowave mechanism, RyR-channels.

Author:
Ryvkin Alexander М. 
e-mail: alex-ryvkin@yandex.ru
Institute of Immunology and Physiology UrB RAS, Ural Federal University named after the first President of Russia B.N. Yeltsin, Russia, Ekaterinburg
620049, Russia, Yekaterinburg, Pervomayskaya St. 106