The Role of Viral Microbiota and Associations with Human Herpes Virus 6 (HHV6) in Children’s Adaptation to Preschool Institutions

Immunology, microbiology, genetics

Kozlova S.N., Savelyeva E.V.

Abstract.
60 children aged 3 to 5 years attending a preschool institution were examined using PCR with qualitative DNA human herpes virus 6 (HHV6), cytomegalovirus (CMV), and Epstein–Barr virus (EBV) indication. The frequency of DNA HHV6, CMV, EBV identification in nasopharyngeal samples was high (93% of children). DNA HHV6 was prevailing in the structure of herpes viruses (53% of children), herpes virus associations were less frequent: DNA HHV6, CMV was identified in 17% of children, DNA HHV6, EBV in 13% of children, DNA HHV6, CMV, EBV in 3% of children; DNA CMV, EBV in 2% of children, DNA EBV in 3% of children, and DNA CMV in 2% of children. The median viral load of DNA HHV6 in nasopharyngeal samples of children was lg3,3 DNA copy/105 cell, DNA CMV lg2,77 DNA copy /105 cell, and DNA EBV lg2,9 DNA copy/105 cell.
The presented research results could be the foundation for the development of preventive and prospective technologies of preparation and adaptation of children to preschool institutions.

Key words:
herpes virus 6, cytomegalovirus, Epstein–Barr virus, children.

Autors:
Kozlova Svetlana N.
Ural State Medical Academy
Russia, 620219, Ekaterinburg, Repina str., 3 
e-mail: AMCSN@yandex.ru

Savelyeva Elena V.
Ural State Medical Academy
Russia, 62019, Ekaterinburg, Repina str., 3