Acute and Chronic Systemic Inflammation: Comparative Analysis

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Gusev E.Yu., Zhuravleva J.A., Zotova N.V., Solomatina L.V., Zubova T.E., Brazhnikov A.Yu., Panshina E.V., Lazareva M.A.

Abstract.
Systemic inflammation (SI) is a phase-specific typical pathological process which has some essential differences from a classical inflammation. The diagnostics of SI requires use of integral criteria including an assessment of blood levels of cytokines and other stress molecules, and a detection of other systemic processes like microthrombosis, organ dysfunction and alteration, distress-reaction of neuroendocrine system. The SI development has three basic scenarios which depend on intensity of systemic damage factors. “A break” and “a caving” are typical of acute SI, and “a sticking” is typical of chronic SI. In this paper we analyze results of a comparison of acute and chronic systemic inflammation integral criteria in 36 groups of patients with different diseases and groups of healthy persons (n=1038). We detected the key role of SI in shock and lethal outcomes in patients from intensive care units and in pathogenesis of chronic diseases and their complications as end-stage renal disease, irreversible critical ischemia of lower limb and systemic lupus erythematosus.

Key words:
systemic inflammation, typical pathological process

Authors:
Gusev Eugeny Yu.
Zhuravleva Julia A.
Zotova Natalia V.
Solomatina Liliya V.
Zubova Tatyana E.
Brazhnikov Anatoly Yu.
Panshina Elena V.
Lazareva Maria A.

Institute of Immunology and Physiology, UB of RAS
Russia, Ekaterinburg, Pervomayskaya str., 106
e-mail: gusev36@mail.ru