The toxic effect of alloxan in the dynamics of the development of alloxan diabetes

The general pathology and pathological physiology

Medvedeva S.J., Bulavintseva T.S., Danilova I.G., Gette I.F., Sentsov V.G.

Abstract.
In order to determine the non-specific toxic effect of alloxan, a morphological study of pancreas, liver, thymus and spleen in rats, after intraperitoneal administration of its 30 mg/100g dose was carried out. The known affinity of alloxan at its early introduction to pancreas β-cells, where in contrast to other examined organs, degenerative-destructive processes are detected, was verified. At later term, (30 days after alloxan introduction) the destructive processes, observed in pancreas, liver and organs of immune system may as well be regarded as secondary, conditioned by persistent hyperglycemia, favoring protein glycolysation and microangiopathy development.

Key words:
alloxan, toxic action, pancreas, thymus, spleen.

Authors
Medvedeva SvetlanaYu.
Institute of Immunology and physiology of the Ural Branch of the Russian Academy of Sciences
Russia, 620049 Yekaterinburg, St. Pervomayskaya, 106

Bulavintseva Tatyana S.
Institute of Immunology and physiology of the Ural Branch of the Russian Academy of Sciences

Danilova Irina G.
Institute of Immunology and physiology of the Ural Branch of the Russian Academy of Sciences; Institute of medical cell technologies

Gette Irina F.
Institute of Immunology and physiology of the Ural Branch of the Russian Academy of

Sentsov Valentin G.
Ural state medical academy
Russia, Yekaterinburg, 620000, Repin St., 3