Influence of Experimental Mother Liver Pathology on the Functional Activity of Alveolar and Peritoneal Posterity Phagocytes

The general pathology and pathological physiology

Shavrina E.Y.

Abstract.
The influence of chronic experimental mother liver defeat (caused by introduction of hepatotropic poison D (+) – galactosamine hydrochloride) on the functional activity of peritoneal and alveolar macrophages of the posterity was studied. Depression of investigated indicators at experimental group that is expressed in suppression of lisosomic and killing activity, oppression of phagocytic properties, and also in decrease of ability to formation of macrophage extracellular traps in vitro was shown. These data can testify to dismaturity, or about depression of functional condition of cages of system of mononuclear phagocytes under the influence of the disturbed metabolic homeostasis caused by mother liver pathology.

Key words:

liver defeat, posterity, macrophages, extracellular traps, killing.

Autor:
Shavrina Ekaterina Y.
FGBOU VPO «Chelyabinsk State University», Chelyabinsk
454001, Russia, Chelyabinsk region, Chelyabinsk, st. Solnechnaya, 70-35.
e-mail: katya_shavrina@mail.ru