Morphological Changes of the Ischemic Brain Tissue of Rats under the Action of Recombinant Erythropoietin in Combination with Laser Radiation

The general pathology and pathological physiology

Giniatullin R.U., Kozel A.I., Popov G. К., Astakhovа L.V., Kuzmin A.N.

Abstract.

The dynamics of the morphological changes in the focus of the experimental cerebral ischemia in rats exposed to recombinant erythropoietin in combination with laser radiation. It is shown that the combined effect of the drug with the physical factor increases in the early stages of experiments tolerance of neurons to hypoxic damage, enhances the proliferation of endothelial cells with the development of new vasculature. This is followed by the earlier regression and disappearance of neurological disorders, improved behavioral responses in experimental animals.

Key words:

brain, ischemia, recombinant erythropoietin, laser radiation.

Authors:

Giniatullin Ravil U.

Kozel Arnold I.

Popov Gennadiy K.

Astakhova Lyudmila V.
Chelyabinsk State Institute of Laser Surgery

Kuzmin Andrey N.
State Budget Institution of Health Regional Clinical Hospital №3, Russia, Chelyabinsk

287, Prospekt Pobedy, Chelyabinsk, Russia, 454021
e-mail: main@cgilh.chel.su