Modulation of Macrophage Activity — the Prospective Use in Treatment of Myocardial Infarction

The general pathology and pathological physiology

Danilova I.G., Medvedeva S.Yu., Yushkov B.G., Gette I.F., Abidov M.T.

Abstract.

The experiment was carried out on 95 outbreed rats. Acute myocardial infarction in rats was induced by left coronary artery coagulation. Derivates of 3-aminophthalhydrazide were used as a modulator of the macrophage activity. Histological study of the myocardium sections and biochemical assays have been carried out on the 1, 5, 7, 14 and 21 days after experimental myocardial infarction. The studies have shown that the modulation of macrophage activity with the derivatives of 3-aminophthalhydrazide reduced the severity of exudative — destructive phase of inflammation in response to injury, which appeared to lessen the area of necrosis in the myocardium.

Key words:

inflammation, myocardial infarction, macrophages

Authors:

Danilova Irina G.

ig-danilova@yandex.ru
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences;
Institute of Medical Cell Technologies
Russian Federation, 620049, Yekaterinburg, Pervomayskaya, 106

Medvedeva Svetlana Yu.

ig-danilova@yandex.ru
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences (IIP UB RAS)
Russian Federation, 620049, Yekaterinburg, Pervomayskaya, 106

Jushkov B.G.

b.jushkov@ iip.uran.ru
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences (IIP UB RAS)
Institute of Medical Cell Technologies
Russian Federation, 620049, Yekaterinburg, Pervomayskaya, 106

Gette Irina F.

i.goette@yandex.ru
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences (IIP UB RAS)
Russian Federation, 620049, Yekaterinburg, Pervomayskaya, 106

Abidov Musa T.

alina144@mail.ru
First Moscow State Medical University I.M. Setchenov
Russian Federation, Moscow, 119991, Trubetskaya, 57