Role of Cell Adhesion Molecule E-cadherin in Normal Cells and Tumor Development

The general pathology and pathological physiology

Zasadkevich Y.M., Sazonov S.V.

Abstract.

E-cadherin — one of the most important cell adhesion molecules in epithelial tissues, which forms adherent junctions between two interacting cells. E-cadherin plays an important role in tissue forming during gastrulation, neurulation and organogenesis. In tissues of adult organism E-cadherin participates in epithelium stratum forming and in signal pathway realization. Downregulation of E-cadherin in tumor development activates signaling cascade and leads to more invasive phenotype of tumor cells, increasing of their migration, survival and distant metastsases development.

Key words:

E-cadherin, cell adhesion molecules, breast cancer, ontogenesis

Authors

Zasadkevich Ylia M.

E-mail: zasadkevich@celltechnologies.ru
GBOU HPE Ural State Medical University of Health Ministry of Russia;
GBUZ SO Institute for Medical Cell Technologies, Ekaterinburg
Russia, 620036, Ekaterinburg, Soboleva, 25.

Sazonov Sergey V.

e-mail: Prof-SSazonov@yandex.ru
GBOU HPE Ural State Medical University of Health Ministry of Russia;
GBUZ SO Institute for Medical Cell Technologies, Ekaterinburg, Russia, 620 036, Ekaterinburg, Soboleva, 25.