Effect of Immunosuppressive Therapy at the Onset of Lupus Nephritis on Remote Renal Prognosis

Duman V.L., Chernysheva N.V.

Ural State Medical University (USMU), RUSSIA, Yekaterinburg, Russian Federation

Abstract. The influence of activity of immunosuppressive therapy (IST) at the onset of lupus nephritis (LN) on renal survival. Retrospectively evaluated for LN 52 patients with various IST in the disease onset. In the first group (1 man and 14 women), cumulative dose (CD) glucocorticoids (GCS) per os for the 1st year LN amounted 198,6±26 mg / kg. Additionally, patients received intravenously pulse therapy (PT) GCS. In group 2 (2 men and 35 women) without PT GCS CD GCS per os was 118,9±6,8 mg/kg. The study revealed that the survival of patients with renal LN positive effect of GCS active therapy in the first year of the disease.

Key words: systemic lupus erythematosus,lupus nephritis, glucocorticoids.

REFERENCES
1. Kozlovskaja L.V., Shilov E.M. Volchanochnyj nefrit, pod red. Muhin N.A. Nefrologija: nacional'noe rukovodstvo [Lupoid Nephrite. Nephrology: National Guideline]. Moscow. GEOTAR-media Publ. 2009. 319-337 p.
2. Tareeva I.E. Porazhenie pochek pri sistemnoj krasnoj volchanke, pod red. Tareeva E.M. Osnovy nefrologii. [Damage of Kidneys at a Systemic Lupus Erythematosus, under the editorship of Tareev E.M. Fundamentals of Nephrology]. Moscow. Medicine Publ. 1972. Vol. 2. pp. 594-626
3. Bono L, Cameron J.S, Hicks J.A. The Very Long-Termprognosis and Complications of Lupus Nephritis and its Treatment. QJMed. – 1999. – №92. – p. 211-218
4. Bagirova V.V., Bugrova O.V. Mechanisms of Progressing of Lupoid Nephrite. Rossijskij pediatricheskij zhurnal — Russian pediatric magazine. 2004. no. 1. pp. 22-26
5. Kozlovskaja N.L., Varshavskij V.A., Shilov E.M., et al. Types of Exacerbations of Lupoid Nephrite and Their Prognostic Value. Terapevticheskij arhiv — Therapeutic Archive. 2008. no. 6. pp. 10-14
6. Tareeva I.E., Bobkova I.N., Kozlovskaja L.V., Mehanizmy progressirovanija glomerulonefrita, pod red. Tareevoj I.E. Nefrologija: Rukovodstvo dlja vrachej [Mechanisms of Progressing of a Glomerulonephritis, under the editorship of Tareeva I.E. Nephrology: Guidelines for Doctors]. Moscow. Medicine Publ., 2000. pp. 224-239
7. Burton C. The role of proteinuria in progression of chronic renal failure. In: Burton C., Harris K.P.G. Amer J Kid Dis. – 1996. – Vol.27, (6). pp. 765-775
8. Bailey R.R, Lynn K.L., Robson R.A., Smith A.H., Wells J.E. Long term follow up of patients with IgA nephropathy. N. Z. Med. J. – 1994. – Vol.107, (976). pp.142-144
9. Shilov E.M., Tareeva I.E., Ivanov A.A., et al. Current and forecast of a mezangioproliferativny glomerulonephritis. Terapevticheskij arhiv — Therapeutic Archive. 2002. Vol. 74, (6). pp. 11-18
10. O'DonoghueD.J., LawlerV.V., HuntL.P., AchesonE.J., MallickN.P. IgM-associatedprimarydiffusemesangialproliferativeglomerulonephritis: Natural history and prognostic indicators. QJMed 1991; Vol.79, (288). – pp. 333-35
11. Batanina N.Ju., Duman V.L. Influence of Immunosupressivny Therapy on Renal Survival at a Mezangioproliferativny Glomerulonephritis with the Isolated Uric Syndrome. Klinicheskaja Nefrologija — Clinical Nephrology. 2010. no. 6. pp. 61–65

Authors
Duman Vyacheslav l.
Chernysheva Natalia V., e-mail: chernysheva333natalia@mail.ru
Ural State Medical University (USMU), RUSSIA, Yekaterinburg, Russian Federation