New Cell Technologies for Recovery of the Endometrium (scientific review).

Veryasov V. N., Vartanyan E. V.

SLL The Clinic of assisted reproductive technologies «Test-tube babies», Moscow, Russia

Abstract.
New areas of regenerative medicine associated with the use of stem/progenitor cells for tissue repair. The most perspective type of progenitor cells for clinical application are mesenchymal stem/stromal cells (MSC). The main properties of MSC, allowing them to successfully carry out the regeneration of tissue, should be attributed to their high proliferative and differentiation potential. MSC can be a precursor tissue-specific cells, as well as to induce regenerative activity of own residual stem cells. This review presents the modern data on MSC, their basic properties, methods and sources, as well as prospects of clinical application of MSC. Special attention is paid to the characteristics of MSC from the endometrial tissue and treatment of various diseases, as well as prospects of recovering their own endometrium.
Keywords:
regenerative medicine, mesenchymal stromal cells, endometrium

REFERENCES
1. Maybin J., Critchley H. Repair and regeneration of the human endometrium. Expert Rev Obstet Gynecol. 2009;4:283–98.
2. Garry R., Hart R., Karthigasu K. A., Burke C. Structural changes in endometrial basal glands during menstruation. BJOG. 2010;117:1175–85
3. Evans J., Kaitu’u-Lino T., Salamonsen L. A. Extracellular matrix dynamics in scar-free endometrial repair: perspectives from mouse in vivo and human in vitro studies. Biol Reprod. 2011;85:511–23.
4. Gargett C. E., Masuda H. Adult stem cells in the endometrium. Mol Hum Reprod. 2010;16:818–34.
5. Maruyama T., Masuda H., Ono M., Kajitani T., Yoshimura Y. Human uterine stem/progenitor cells: their possible role in uterine physiology and pathology. Reproduction. 2010;140:11–22.
6. Sara S. Morelli, Pranela Rameshwar, and Laura T. Goldsmith. Experimental Evidence for Bone Marrow as a Source of Nonhematopoietic Endometrial Stromal and Epithelial Compartment Cells in a Murine Model. Biol.Reprod.2013; 89(1):7, 1–7
7. C. E. Gargett, “Uterine stem cells: what is the evidence?” Human Reproduction Update. 2007; 13(1): 87–101,
8. R.W. S. Chan, K. E. Schwab, and C. E. Gargett, “Clonogenicity of human endometrial epithelial and stromal cells,” Biology of Reproduction. 2004; 70(6): 1738–1750.
9. C. E. Gargett, K. E. Schwab, R.M. Zillwood, H. P. T. Nguyen, and D.Wu, “Isolation and culture of epithelial progenitors and mesenchymal stem cells from human endometrium,” Biology of Reproduction, 2009; 80(6): 1136–1145
10. K. Kato, M. Yoshimoto, K. Kato et al., “Characterization of side-population cells in human normal endometrium, ”Human Reproduction, 2007; 22(5): 1214–1223.
11. Friedenstein, A.J., Petrakova, K.V., Kurolesova, A.I., Frolova, G.P., Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation 1968;6: 230–247.
12. Parker AM, Katz AJ: Adipose-derived stem cells for the regeneration of damaged tissues. Expert Opin Biol Ther 2006; 6(6):567-78.
13. Gronthos, S., Mankani, M., Brahim, J., Robey, P.G., and Shi,S. Postnatal human DP stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A 2000;97, 13625.
14. Erices, P. Conget, and J. J. Minguell, “Mesenchymal progenitor cells in human umbilical cord blood,” British Journalof Haematology 2000;109 (1): 235–242.
15. Veryasov V., Savilova A., Buyanovskaya O., et.al. Getting mesenchymal stromal cells of non-embryonic tissues and their characteristics. Cell technologies in biology and medicine. 2014;1:3-5.
16. C. E. Gargett and H. Masuda, “Adult stem cells in the endometrium,”Molecular Human Reproduction, 2010;16 (11):818–834.
17. M Dominici, K Le Blanc, I Mueller, at al. “Criteria for defining multipotent mesenchymal stromal cells.” The International Society for Cellular Therapy position statement. Cytotherapy, 2006; 8 (4): 315-317.
18. Masuda, Hirotaka; Anwar, Siti S.; Bühring, Hans-Jörg; Rao, Jyothsna R.; Gargett, Caroline E. “A Novel Marker of Human Endometrial Mesenchymal Stem-Like Cells” Cell Transplantation, 2012; 21(10): 2201-2214.
19. Mobarakeh ZT, Ai J, Yazdani F, et al. “Human endometrial stem cells as a new source for programming to neural cells”. Cell Biol Intern Rep, 2012;19(1): 7-14
20. Santamaria X, Massasa EE, Feng Y, et al. “Derivation of insulin producing cells from human endometrial stromal stem cells and use in the treatment of murine diabetes”. Mol Ther, 2011;19(11):2065-71
21. Huang Y, et al: “Effect of fluid shear stress on cardiomyogenic differentiation of rat bone marrow mesenchymal stem cells”. Arch Med Res, 2010; 41(7):497–505.
22. Leo Bockeria, Vladimir Bogin, Olga Bockeria, et al: “Endometrial regenerative cells for treatment of heart failure: a new stem cell enters the clinic”, Journal of Translational Medicine, 2013; 11:56-62.
23. Jeffery J. Auletta, Robert J. Deans and Amelia M. Bartholomew. “Emerging roles for multipotent, bone marrow-derived stromal cells in host defense”, BLOOD, 2012; 119 (8): 1801- 1819
24. Anna Krasnodemskaya, Yuanlin Song, Xiaohui Fang, et al: “Antibacterial Effect of Human Mesenchymal Stem Cells Is Mediatedin Part from Secretion of the Antimicrobial Peptide LL-37” STEM CELLS, 2010;28:2229–22
25. Karen English and Kathryn J. Wood “Mesenchymal Stromal Cells in Transplantation Rejection and Tolerance” Cold Spring Harb Perspect Med, 2013; doi: 10.1101/cshperspect.a015560
26. Le Blanc, K., Rasmusson, I., Sundberg, B., et.al: “Treatment of severe acute graft-versushost disease with third party haploidentical mesenchymal stem cells”. Lancet, 2004; 363: 1439–1441
27. Himes, B.T., Neuhuber, B., Coleman, C., et.al: “Recovery of function following grafting of human bone marrow-derived stromal cells into the injured spinal cord”. 2006. Neurorehabil.Neural Repair; 20: 278–296.
28. Park, H.J., Lee, P.H., Bang, O.Y., Lee, G., Ahn, Y.H. “Mesenchymal stem cells therapy exerts neuroprotection in a progressive animal model of Parkinson’s disease”. J. Neurochem. 2008:107, 141-146.
29. Zhang, J., Li, Y., Lu, et.al: “Bone marrow stromal cells reduce axonal loss in experimental autoimmune encephalomyelitis mice”. J. Neurosci. Res. 2006: 84, 587–595.
30. Choi, M.R., Kim, H.Y., Park, et.al: “Selection of optimal passage of bone marrow-derived mesenchymal stem cells for stem cell therapy in patients with amyotrophic lateral sclerosis”. Neurosci. Lett, 2010; 472: 94–98.

31. Wang, J., Bian, C., Lia et.al: “ Inhibition of hepatic stellate cells proliferation by mesenchymal stem cells and the possible mechanisms”. Hepatol. Res., 2009; 39: 1219–1228.

32. Paul, D., Samuel, S.M., Maulik, N., “Mesenchymal stem cell: present challenges and prospective cellular cardiomyoplasty approaches for myocardial regeneration”. Antioxid. Redox Signal., 2009; 11: 1841–1855.
33. Park, K.S., Kim, Y.S., Kim, et.al: J.H., Choi, B., Kim, S.H., Tan, A.H., Lee, M.S., Lee, M.K., Kwon,C.H., Joh, J.W., Kim, S.J., Kim, K.W., “Trophic molecules derived from human mesenchymal stem cells enhance survival, function, and angiogenesis of isolatedislets after transplantation”. Transplantation, 2010; 89: 509–517.
34. Wu, Y., Chen, L., Scott, P.G., Tredget, E.E. “ Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis”. Stem Cells, 2007; 25: 2648–2659
35. Chen, F.H., Tuan, R.S., “Mesenchymal stem cells in arthritic diseases”. Arthritis Res. Ther., 2008;10: 223-226.
36. Nuray Kusadasi and A. B. Johan Groeneveld “A perspective on mesenchymal stromal cell transplantation in the treatment of sepsis“. Shock, 2013; 40(5): 352-357,
37. Lalu MM, McIntyre L, Pugliese C, et.al: “ Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials”. PLoS One. 2012;7(10).
38. Zhong Z, Patel AN, Ichim TE, et al; “Feasibility investigation of allogeneic endometrial regenerative cells”. J Transl Med, 2009;7:15-22.
39. Ichim TE, Alexandrescu DT, Solano F, et al. “Mesenchymal stemcells as antiinflammatories: implications for treatment of Duchenne muscular dystrophy”. Cell Immunol, 2010;260(2):75-82
40. Bockeria L, Bogin V, Bockeria O, et al. Endometrial regenerative cells for treatment of heart failure: a new stem cell enters the clinic. J Transl Med 2013;11:56
41. Human menstrual blood-derived mesenchymal stem cells for patients withliver cirrhosis. 2013. Available from: http://clinicaltrials. gov/ct2/show/NCT01483248? term=menstrual+blood+cells&rank=1[Cited 21 April 2013]
42. Phase I/II Trial of Endometrial Regenerative Cells (ERC) in patients with critical limb ischemia. 2013. Available from: http://clinicaltrials. gov/ct2/show/NCT01558908?term=NCT01558908&rank=1 [Cited 1 April 2013]
43. Ichim TE, Solano F, Lara F, et al. Combination stem cell therapy for heartfailure. Int Arch Med 2010;3(1):5-5
44. Role of stem cells in improving implantation rates in ICSI Patients. 2013. vailable from: http://clinicaltrials.gov/ct2/show/NCT01649752?term=endometrial+regenerative +cells&rank=2 [Cited 21 April 2013]

Authors
Veryasov Valery N.
biologist, Ph D
e-mail: valeriverjas@mail.ru

Vartanyan Emma V.
obstetrician-gynecologist, (reproduction), MD. Director
e-mail: emma-vartanyan@mail.ru
Clinic of assisted reproductive technologies «Test-tube babies»
2, Shchukin street, 123182, Moscow, Russian Federation