Prevalence of Inherited Thrombophilia in Patients with Infertility and Fertile Women (Comparative Analysis)
Mayasina E. N., Oboskalova T. A., Voroshilina E. S., Askerov R. A., Plotko E. E.
Joint stock company «Сentre of Family Medicine», Ekaterinburg, Russian Federation;
The State Budgetary Educational Establishment of Higher Professional Education
«The Ural's State Medical Academy» of Mnistry of Health of Russian Federation, Ekaterinburg, Russian Federation;
Society with Limited Liability Medical and Pharmaceutical Сenter «Harmony», Ekaterinburg, Russian Federation
Abstract.
The aim of the study: to determine prevalence of inherited thrombophilia in patients who are planning programmes of in vitro fertilization and pregnant women without a history of infertility. The authors conducted a retrospective analysis of incidence of congenital thrombophilia in 230 women planning IVF (group 1) and 86 pregnant women with no history of infertility (group 2). No reliable differences in frequency of mutations of genes of hemostasis. The first group was significantly higher than the prevalence of mutations in metilentetragidrofolatreduktazy, but only geterozigotnom version: 52.6 % in the first group and 37.6 % in the second group. Also in patients with infertility higher homozygous form of the mutation of fibrinogen, the prevalence was 5 % and 1.2 %, respectively, of the research group.
Keywords:
IVF, inherited thrombophilia, infertility, pregnancy loss
REFERENCES
1. Zajnullina M.S., Kornushina E.A. Hemostatic disorders, methods of correction and pregnancy outcomes in patients with thrombophilia and recurrent pregnancy loss. Thrombosis, hemostasis and rheology, N 4, 2009. 71-78 pp. in Rus
2. Makatsaria A.D., Bitsadze V.O. Thrombophilia and antithrombotic therapy in obstetrics. М.: «Triada-Х», 2003. 904 p. in Rus
3. Makatsaria A.D., Bitsadze V.O., Baimuratova S.M. et al.. Prevention of recurrent pregnancy complications with thrombophilia (a syndrome of loss fetus, gestoses, premature detachment normally situated placenta, thrombosis and embolism). М.: «Triada-Х», 2008. 152 p. in Rus.
4. Lund M., Nielsen H.S., Hviid T.V., Steffensen R., Nyboe Andersen A, Christiansen O.B. Hereditary thrombophilia and recurrent pregnancy loss: a retrospective cohort study of pregnancy outcome complications. Human Reproductoin, No. 12, 2010. 2978-84 p.
5. Sucak A., Acar K., Celen S., Danisman N., Sucak G.T. Outcome of pregnancies in women with thrombophilic disorders. J Obstet Gynaecol., 2010; 30(8). 847-51 p.
6. Said J.M., Higgins J.R., Moses E.K., Walker S.P., Borg A.J., Monagle P.T., Brennecke S.P. Inherited thrombophilia polymorphisms and pregnancy outcomes in nulliparous women. Obstet Gynecol., 2010; 115(6). 1305-6 p.
7. Qublan H.S., Eid S.S., Ababneh H.A., Amarin Z.O., Smadi A.Z., Al-Khafaji F.F., Khader Y.S. Acquired and inherited thrombophilia: implication in recurrent IVF and embryo transfer failure. HumReprod. Oct; 21(10), 2006. 2694-8 p.
8. Coulam C.B., Jeyendran R.S., Fishel L.A., Roussev R. Multiple thrombophilic gene mutations are risk factors for implantation failure. Reprod Biomed Online, Mar; 12(3), 2006. 322-7 p.
9. Azem F., Many A., Yovel I., Amit A., Lessing J.,Kupferminc M. Increased rates of thrombophilia in women with repeated IVF failures. Human Reproduction Vol 19, No.2, 2004. 368-370 pp.
10. Vaquero E., Lazzarin N., Caserta D., Valensise H., Baldi M., Moscarini M.M., Arduini D. Diagnostic evaluation of women experiencing repeated in vitro fertilization failure. Eur J Obstet Gynecol reprod Biol., Mar 1; 125 (1), 2006. 79-84 pp.
11. Simur A., Ozdemir S., Acar H., Colakoğlu M.C., Görkemli H., Balci O, Nergis S. Repeated in vitro fertilization failure and its relation with thrombophilia. Gynecol. Obstet. Invest 67(2), 2009. 109-12 p.
12. Ricci G., Bogatti P., Fischer-Tamaro L., Giolo E., Luppi S., Montico M., Ronfani L., Morgutti M. Factor V Leiden and prothrombin gene G20210A mutation and in vitro fertilization: prospective cohort study. Hum Reprod., Nov., 2011, 26(11). 3068-77p.
13. Prjadko S.I., Samuilova D.Sh., Patrushev L.I., Dzhabaeva M.S. Genetic polymorphism of factors of a fibrillation at patients with venous thrombosis and a varicose illness. Grudnaja i serdechnososudistaja hirurgija — Chest and cardiovascular surgery, No. 1, 2010. 49-53 pp.
14. Machac S., Lubusky M., Prochazka M., Streda R. Prevalence of inherited thrombophilia in patients with severe ovarian hyperstimulation syndrome. Biomed Pap Med FacUnivPalacky Olomouc Czech Repub. Nov, 2006; 150(2). 289-92 p.
15. Rudick B., Su H.I., Sammei M.D., Kovalevsky G., Shaunik A., Barnhart K. Is factor V Leiden mutation a cause of in vitro fertilization failure? Fertil Steril. Oct 2009; 92 (4).1256-9 p.
16. Ivanov P., Komsa-Penkova R., Kovacheva K., Konova E., Todorova K., Simeonova M., Ivanov I., Stoĭkov S., Popov I., Tanchev S., Bozhinova S. Risk of thrombophilia in carriers of thrombophilic genetic factors in unsuccessful assisted reproduction. AkushGinekol (Sofiia). 2007; 46(6). 3-8 p.
17. Pacchiarotti A., Mohamed M.A., Micara G., Linari A., Tranquilli D., Espinola S.B., Aragona C. The possible role of hyperhomocysteinemia on IVF outcome. J Assist Reprod Genet. Oct 2007; 24(10). 459-62 p.
18. Arzhanova O. N, Aljab'eva E. A., Shljahtenko T. N. Gipergomotsisteinemiya at women with habitual not incubation of pregnancy. Ginekologija — Ginecology. 2009. No. 5. 23-36 pp.
19. Jeddi-Tehrani M., Torabi R., Zarnani A.H., Mohammadzadeh A., Arefi S., Zeraati H., Akhondi M.M., Chamani-Tabriz L., Idali F., Emami S., Zarei S. Analysis of plasminogen activator inhibitor-1, integrin beta3, beta fibrinogen, and methylenetetrahydrofolate reductase polymorphisms in Iranian women with recurrent pregnancy loss. J Reprod Immunol. Jan. 2011 Jan 18. 1600-1608 p.
20. Mohamed M.A., Moaty M.A., Kholy A.F., Mohamed S.A., Ali A.I. Thrombophilic gene mutations in women with repeated spontaneous miscarriage. Genet Test Mol Biomarkers. Oct. 2010. 14(5). 593-7 p.
Authors
Mayasina Elena N.
Joint stock company «Сentre of Family Medicine»
1/3, Nachdiva Vasilieva str., 620102, Ekaterinburg, Russian Federation
The State Budgetary Educational Establishment of Higher Professional education «The Ural's State Medical Academy» of Mnistry of Ytalth of Russian Federation, Department of obstetrics and gynecology of the medical-prophylactic faculty
3, Repina str., 620219 Ekaterinburg, Russian Federation
e-mail: elena.mayasina@gmail.com
Oboskalova Tatiana A.
The State Budgetary Educational Establishment of Higher Professional education «The Ural's State Medical Academy» of Mnistry of Ytalth of Russian Federation, Department of obstetrics and gynecology of the medical-prophylactic faculty; prof., MD
3 Repina str., 620219 Ekaterinburg, Russian Federation
Voroshilina Ekaterina S.
Society with Limited Liability Medical and Pharmaceutical center «Harmony» Ekaterinburg, MD
16 Tveritina str., Ekaterinburg, Russian Federation
e-mail: voroshilina@gmail.com
Askerov Roman A.
Joint stock company «Сentre of Family Medicine»
1/3. Nachdiva Vasilieva str., 620102 Ekaterinburg, Russian Federation
e-mail: roman.askerov@gmail.com
Plotko Evgeny E.
Society with Limited Liability Medical and Pharmaceutical center «Harmony»
16 Tveritina str., Ekaterinburg, Russian Federation