Immunological Reactivity in Men with Hypertension in Arctic Conditions
Morozova O.S., Popovskaya E.V.
Federal state institution of science Institute of physiology of the natural adaptations of Sciences, Arkhangelsk, Russian Federation
Abstract.
Arterial hypertension (AH) is the most common chronic disease, increasing mortality and worsen the prognosis of life of the population. Arterial hypertension is a leading risk factor for severe cardiovascular disease (CVD) — myocardial infarction, stroke, heart failure, and renal failure.
The analysis of clinical and laboratory data 31 men aged 22-44 years, residents Arkhangelsk, suffering from arterial hypertension. In the peripheral blood of the examined were: the concentration of phenotypes lymphocytes CD3+, CD4+, CD5+, CD8+, CD10+, CD16+, CD22+, CD71+, CD95+, CDHLADR+; the percentage of active phagocytes (neutrophils in the blood), phagocytic number.
In men with hypertension revealed secondary ecologically dependent immunodeficiencies, manifested in the failure of T-cell immunity (CD3+) have 90,90±3,06% of persons; (CD5+) have 100,00±3,20% of the people; decrease phagocytic activity on the background of a marked lymphoproliferative (CD10+) have 45,45±2,16% of the surveyed. A higher content of concentration of cytotoxic T-lymphocytes in 68,18±2,65% of the examined persons.
Key words:
arterial hypertension, lymphocyte phenotypes, the Arctic.
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Authors
Morozova Olga S.
olia.morozow2011@yandex.ru
Federal state institution of science Institute of physiology of the natural adaptations of Sciences, Arkhangelsk
Candidate of biological Sciences; research associate.
Russian Federation 163000, Arkhangelsk, Lomonosova 249
Popovskaya Ekaterina V.
eli1255@ya.ru
Establishment of health care JSC «First city clinical hospital E.E. Volosevich», Arkhangelsk
Physician of the Department of neurosurgery.
Russian Federation 163001, Arkhangelsk, street Suvorova 1