ADAPTIVE AGING CHANGES OF OMEGA-7 MONOUNSATURATED FATTY ACID AND PARAMETERS OF CARBOHYDRATE METABOLISM IN BLOOD OF INHABITANTS OF THE NORTH OF RUSSIA
DOI: 10.22138/2500-0918-2018-15-2-151-161
F.A. Bichkaeva, N.I. Volkova, A.A. Lobanov, R.A. Kochkin
Federal Center for Integrated Arctic Research, Russian Academy of Sciences, Arkhangelsk, Russian Federation;
State institution Arctic Research Center of the Yamal-Nenets autonomous district, Salekhard, Russian Federation
Abstract: Aim. Тo estimate level and identify the character of relationship between maintenance of omega-7 monounsaturated fatty (MSF) and metabolites of carbohydrate metabolism in relation to age of almost healthy inhabitants of the north of Russia in different climatographical areas. Materials and methods. In the period of prolongated daylight 1716 inhabitants were observed: 897 — inhabitants of Priarctic Region (PR) and 819 of Arctic Region (AR). Quantity of omega-7 MSF was identified using gas-liquid chromatography, spectrographic method was used for identifying parameters of carbohydrate metabolism. Results and conclusions. People of 46–60 and 61–74 age, inhabitants of PR and AR has higher level of palmitoleic acid (С16:1n7с), comparing to people of 16–21 age, also higher level of heptodecanic (С17:1n7с) comparing to people of 36–45 age, what is important — high frequency of higher than normal levels goes with increased level of glucose (GLU), Lactate (LAC), LAC\PIR, with higher proportion, especially of GLU, in AR. In all age groups of both regions level of С16:1n7с is shifted to the lower level of normal ranges, but the percentage of people with deficiency is becoming lower, and with excess – increases. Level of palmitoelandinic acid (С16:1n7t) in PR is increasing with the age, and in AR is decreasing, at the same tine most of the inhabitants with its excess in AR are 36–45 years old, and in PR 46–60. Identified in both regions shift of С16:1n7с with the age to the lower normal range and of С16:1n7t to the higher normal range, most possibly reflects the change in pancreatic hormones activity, and it is proved by increase of GLU and its metabolites level. Correlation mining shows that maximum GLU level in the people of 46–60 and 61–74 age, inhabitants of both regions and people of 46–60 age of PR its level depends on С17:1n7, and in the people of 46–60 and 61–74 age inhabitants of AR it depends on С16:1n7, С17:1n7 and Omega-7 MSF.
Keywords: ω-7 monounsaturated fatty (MSF), carbohydrate metabolism, age, Arctic
Received 09.04.2018
For citation:
Bichkaeva F.A., Volkova N.I., Lobanov A.A., Kochkin R.A. Adaptive Aging Changes of Omega-7 Monounsaturated Fatty Acid and Parameters of Carbohydrate Metabolism in Blood of Inhabitants of the North of Russia. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2018, Vol. 15, no. 2, pp. 151–161 DOI: 10.22138/2500-0918-2018-15-2-151-161 (In Russ)
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Authors
Fatima A. Bichkaeva
Federal Center for Integrated Arctic Research, Russian Academy of Sciences
Dr. Sci.(Biol.), Chief research scientist, Head of laboratory of biologicheskoy i neorganicheskoy khimii
Russian Federation, 163000, Arkhangelsk, Lomonosova Ave., 249
fatima@fciarctic.ru
Natalja I. Volkova
Federal Center for Integrated Arctic Research, Russian Academy of Sciences
Cand. Sci.(Biol.), Senior research assistant
Russian Federation, 163000, Arkhangelsk, Lomonosova Ave., 249
natalja200958@mail.ru
Andrey A. Lobanov
State institution YNAO «Scientific center of Arctic research»
Dr. Sci. (Med.), Deputy director
Russian Federation, 629008, Salekhard, Respubliki str., 73
Alobanov89@gmail.com
Ruslan A. Kochkin
State institution YNAO «Scientific center of Arctic research»
Cand. Sci.(Med.), Senior research assistant of the medical research sector
Russian Federation, 629008, Salekhard, Respubliki str., 73
kochkin25011983@mail.ru
