The adaptive immune response from the students of Northern State Medical University

DOI: 10.22138/2500-0918-2019-16-2-159-164

O.S. Morozova, E.Y Shashkova, O.E. Filippova, M.V. Menshikova

Federal state budgetary institution of science of the Federal research center for integrated study of the Arctic named after academician N.P. Laverov, Russian Academy of Sciences, Arkhangelsk, Russian Federation;
Federal state budgetary educational institution of higher education «Northern state medical university», Arkhangelsk, Russian Federation

Abstract. Environmental problems in uncomfortable climatic and geographical conditions of life provide not just a summation of different factors of adverse effects, but sometimes an increase in the order of magnitude and more negative impact of each of them. Extreme climatoecological conditions of the North prevent the development of self-regulation processes that return the system to the optimal mode of functioning, which leads to the activation and tension of cellular and humoral immunity and, ultimately – to reduce the reserve capacity of the body. The purpose of the work is to determine the features of the immune status of students 18-29 years old studying at the Northern state medical University, Arkhangelsk. Materials and methods of research. A survey of 30 healthy female students of 1-2 courses (according to the medical cards of the health center of the NSMU), aged 18-29 years, studying at the Northern state medical University, Arkhangelsk. Blood for analysis in volunteers was taken from the ulnar vein in the amount of 6 ml. at 9-10 o'clock in the morning, on an empty stomach. Immunological studies conducted in the laboratory of physiology of immune cells, IFPA, VICKIE RAS, Arkhangelsk, using microscope Nikon Eclipse 50i. The content of phenotypes of CD4+, CD5+, CD8+, CD20+, CD95+; lymphocytes was studied in peripheral blood;the structure of leukogram was determined. Results. The examined students of the Northern state medical University were found to have reduced reserve capabilities of immune homeostasis due to increased cytotoxic activity (CD8+) in 56,66±2,49%, increased apoptosis activity (CD95+) in 53,33±2,42% of patients, against the background of a deficit of total T-lymphocytes (CD5+) in 90,00±3,14% of the examined. Have 16,66±1,35% of the surveyed students was lymphocytosis; lymphopenia meet 13,33±1,21% cases; monocytes from 10,00±1,04% of the surveyed students; neutropenia was observed in 33,33±1,91% of the students. Conclusions: the revealed immune imbalances and their wide frequency of distribution can be the cause of environmentally-dependent immunodeficiency, reduce the effectiveness of adaptive immune responses and the development of possible chronic pathology.

Keywords: lymphocyte Phenotypes, monocytes, adaptive immunity, North

Received 15.04.2019.

For citation:
Morozova O.S., Shashkova E.Y., Filippova O.E., Menshikova M.V. The adaptive immune response from the students of Northern State Medical University. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2019, Vol. 16, no. 2, pp. 159–164. DOI: 10.22138/2500-0918-2019-16-2-159-164 (In Russ)

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Authors
Olga S. Morozova
Federal state budgetary institution of science of the Federal research center for integrated study of the Arctic named after academician N. P. Laverov Russian Academy of Sciences
Cand. Sci. (Biology), Researcher
Lomonosova av. 249 Arkhangelsk Russian Federation 163000
olia.morozow2011@yandex.ru

Elizaveta Y. Shashkova
Federal state budgetary institution of science of the Federal research center for integrated study of the Arctic named after academician N. P. Laverov, Russian Academy of Sciences
Cand. Sci. (Biology), Senior Researcher
Lomonosova av. 249 Arkhangelsk Russian Federation 163000
eli1255@yandex.ru

Oksana E. Filippova
Federal state budgetary institution of science of the Federal research center for integrated study of the Arctic named after academician N. P. Laverov, Russian Academy of Sciences
Cand. Sci. (Biology), Senior Researcher
Lomonosova av. 249 Arkhangelsk Russian Federation 163000
oxana_filippova_85@mail.ru;

Marina V. Menshikova
Federal state budgetary educational institution of higher education «Northern state medical university» of the Ministry of health of the Russian Federation
Cand. Sci. (Biology), Associate Professor of histology, Cytology and embryology
Troitsky av. 51 Arkhangelsk Russian Federation 163000
menshikovamv1961@yandex.ru

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