T-cell activity in the northern population

DOI: 10.22138/2500-0918-2019-16-2-128-133

УДК 612.112.94 (470)

M.S. Kabbani, T.B. Sergeeva, L.S. Shchegoleva

Northern (Arctic) Federal University of M.V. Lomonosov, Arkhangelsk, Russian Federation;
Federal state budgetary institution of science Federal research center of complex studying of the Arctic of a name of the academician N.P. Laverov of the Russian Academy of Sciences, Arkhangelsk, Russian Federation

Abstract. T-lymphocyte activity is considered to be an important factor in determining the quality of public health, especially for people living in high latitudes, since they are exposed to the effects of harsh climatic and ecological living conditions. This work is aimed to identify the activity of T-lymphoid cells in women living in the northern regions. The analysis included determination of lymphoid subpopulations (CD5+, CD71+, CD95+) in 40-60-year-old women living in Vologda, Pinega settlement and Nadym. For that, we used the indirect immunoperoxidase assay with monoclonal antibodies. The obtained data showed a sharp decrease in the concentration of lymphoid cells with CD5+ receptors in all (100%) examined individuals, a moderate increase in cells with transferrin receptors in 58%, 47% and 16% of women (respectively), elevated concentrations of cells with receptors for apoptosis were detected in 35% of women, and lower concentrations in 44% of individuals, regardless of the residence area. The living conditions in the North can contribute to the development of secondary ecologically dependent immunodeficiencies in humans and, as a consequence, to the emergence of the potential regional pathology. Additional researches are required to identify the mechanisms of changing T-cells activity in humans in the North during the formation of an adaptive immune response with the aim of further developing preventive measures to prevent the development of secondary environmentally dependent immunodeficiencies.

Key words: Lymphocytes, lymphoid subpopulations, receptors, трансферрин and apoptosis

Received 15.04.2019.

For citation:
Kabbani M.S., Sergeeva T.B., Shchegoleva L.S. T-cell activity in the northern population. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2019, Vol. 16, no. 2, pp. 128–133. DOI: 10.22138/2500-0918-2019-16-2-128-133 (In Russ)

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Аuthors
Mohammad S. Kabbani
Northern (Arctic) Federal University of M.V. Lomonosov
PhD student, Assistant
Northern Dvina nab. 17 Arkhangelsk Russian Federation 163000
sohibmsk@hotmail.com

Tatyana B. Sergeeva
Federal Center for Integrated Arctic Research Russian Academy of Sciences of the Academician N.P. Laverov
Cand. Sci. (Biology), Senior Scientist on Laboratory of physiology of immunocompetent cells
Lomonosov av. 249 Arkhangelsk Russian Federation 163000

Lyubov S. Shchegoleva
Federal Center for Integrated Arctic Research Russian Academy of Sciences of the Academician N.P. Laverov
Dr. Sci. (Biology), Professor, Head of the laboratory of physiology of immunocompetent cells
Northern Dvina nab. 17 Arkhangelsk Russian Federation 163000
Shchegoleva60@mail.ru

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