ACTIVITY OF NUCLEOLAR ORGANIZER REGIONS IN MENSTRUAL ENDOMETRIAL CELLS FROM WOMEN WITH ENDOMETRIOSIS
DOI: 10.22138/2500-0918-2018-15-6-824-829
E.L. Kurenkov, E.V. Igenbaeva, T.V. Uzlova
South-Ural State Medical University, Chelyabinsk, Russian Federation
Abstract. Relevance. Endometriosis is a gynecological disease characterized by a benign proliferation of tissue, similar in morphological structure and function to the endometrium, outside the uterus. After its publication in 1927, the Sampson theory gave rise to a stream of other studies dedicated to biological properties of eutopic endometrial cells in women with endometriosis. Objective. To evaluate the activity of the nucleolar organizer regions in epithelial cells and lamina propria cells in women with external genital endometriosis and without it in the menstrual phase. Materials and methods. For the study, menstrual flows were collected using menstrual cups. The study included 10 women with external genital endometriosis (group 1) and 8 women without external genital endometriosis (group 2) according to laparoscopy data. The activity of nucleolar organizer regions was assessed by J. Crocker method. Results. When assessing the activity of nucleolar organizer regions in epithelial cells and lamina propria cells of the menstrual discharge, a significantly higher activity of nucleolar organizer regions in women with external genital endometriosis was revealed, indicating a higher degree of ribosomal synthesis intensity in these cells. Conclusion. In the endometrial cells of menstrual discharge in women with external genital endometriosis, a significantly higher activity of nucleolar organizer regions is observed, which may be of clinical interest for developing methods for non-invasive diagnosis of this pathology.
Keywords: endometriosis, endometrium, menstrual phase, nucleolar organizer regions
There is no conflict of interest.
Contact details of the corresponding author:
Elena V. Igenbaeva
bulba2606@mail.ru
Received 27.11.2018
For citation:
Kurenkov E.L., Igenbaeva E.V., Uzlova T.V. Activ¬ity of nucleolar organizer regions in menstrual endome¬trial cells from women with endometriosis. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2018, Vol. 15, no. 6, pp. 824–829. DOI: 10.22138/2500-0918-2018-15-6-824-829 (In Russ).
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Authors:
Evgeny L. Kurenkov
Dr. Sci. (Med.), Professor, Head of the Department of
Human Anatomy
kurenkovel@chelsma.ru
Elena V. Igenbaeva
Gynecologist
Gynecological department of the Clinic
bulba2606@mail.ru
Tatyana V. Uzlova
Dr. Sci. (Med.), Professor of the Department of Obstetrics
and Gynecology
tatiana.uzlova@mail.ru
South-Ural State Medical University
Vorovskogo Str., 64, Chelyabinsk, Russian Federation,
454092
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)