Analis of distribution are B-lymphocytes spleen in aplastic anemia patients
DOI: 10.22138/2500-0918-2017-14-1-62-66
N.S. Fedorovskaya, D.A. Diakonov, V.B. Zaitsev,
N.L. Kochetov, V.A. Rosin, E.A. Perfilova
Kirov Research Institute of Hematology and Blood Transfusion of Federal Medical and Biologic Agency, Kirov, Russian Federation;
Kirov State Medical Academy, Kirov, Russian Federation
Abstract. The aim of this work is research of B-lymphocytes distribution in spleen apalastic anemia patients depending on the severe and pathological process during before spleenectomy. Analysis В-cells performed to 33 patients. In results of researching was found increase quantity of CD20+ и CD79?+ expressing lymphoid elements in histological section of spleen in bone marrow aplasia patients independent from disease severe. The increasing of content В-lymphocytes population was more expressed in red pulp organ. Besides found, what CD20+ positive cells level are depended from deadline of spleenectomy. Results from this study are supplement performance about histological spleen changes in aplastic anemia.
Keywords: aplastic anemia, immunohistochemistry, В-limphocytes, spleen
Received 12.01.2017
For citation:
Fedorovskaya N.S., Diakonov D.A., Zaitsev V.B., Kochetov N.L., Rosin V.A., Perfilova E.A. Analis of distribution are B-lymphocytes spleen in aplastic anemia patients. Vestn. Ural. Med. Akad. Nauki. Journal of Ural Medical Academic Science. 2017, Vol. 14, no. 1, pp. 62–66. DOI: 10.22138/2500-0918-2017-14-1-62-66 [In Russ.]
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Authors
Nadejda S. Fedorovskaya
Kirov Research Institute of Hematology and Blood Transfusion of Federal Medical and Biologic Agency
Сand. Sci. (Med.), Head of Laboratory Pathomorphology of Blood
Str. Krasnoarmejskaja 72, Kirov, Russian Federation, 610027
fednadst@mail.ru
Dmitriy A. Diakonov
Kirov Research Institute of Hematology and Blood Transfusion of Federal Medical and Biologic Agency
Сand. Sci. (Med.), Senior Researcher of Laboratory Pathomorphology of Blood
Str. Krasnoarmejskaja 72, Kirov, Russian Federation, 610027
DiakonovDA@rambler.ru
Valeri B. Zaitsev
Kirov State Medical Academy
Dr. Sci. (Med.), Professor, Chairman of Dept. of Histology, Embryology and Cytology
Str. Karl Marx, 112, Kirov, Russian Federation, 610027
zaitsev@kirovgma.ru
Nikolai L. Kochetov
Kirov Research Institute of Hematology and Blood Transfusion of Federal Medical and Biologic Agency
Pathologist of Laboratory Pathomorphology of Blood
Str. Krasnoarmejskaja 72, Kirov, Russian Federation, 610027
skorpionx@yandex.ru
Vitaliy A. Rosin
Kirov Research Institute of Hematology and Blood Transfusion of Federal Medical and Biologic Agency
Сand. Sci. (Med.), Senior Researcher of Laboratory Pathomorphology of Blood
Str. Krasnoarmejskaja 72, Kirov, Russian Federation, 610027
vitalyarosin@yandex.ru
Elena A. Perfilova
Kirov Research Institute of Hematology and Blood Transfusion of Federal Medical and Biologic Agency
Сand. Sci. (Med.), Junior Researcher of Laboratory Pathomorphology of Blood
Str. Krasnoarmejskaja 72, Kirov, Russian Federation, 610027
perfl78@mail.ru
