Antibacterial and Antimycotic Properties of Granularcarbon Sorbents
DOI: 10.22138/2500-0918-2017-14-2-164-170
V. T. Dolgikh, L. G. Pjanova, V. A. Likholobov, A. V. Lavrenov,
N. V. Rudakov,M. G. Chesnokova, A. V. Sedanova, V. V. Rusakov, O. V. Korpachova
Omsk State Medical University, Omsk, Russian Federation;
Institute of Hydrocarbons Processing SB RAS, Omsk, Russian Federation
Abstract. The aim is to investigate the antibacterial and antimycotic properties of modified carbon sorbents in relation to pathogenic and opportunistic microorganisms. Materials and methods. The studies were carried out in two stages: at the first stage, the sensitivity of microorganisms to the antibiotics most often used in the clinic was evaluated, and in the second stage — the antimicrobial resistance of 4 carbon sorbents. The results of microbiological bench studies to determine the antibacterial and antimycotic activity of the carbon sorbents modified by the oligomers of lactic and glycolic acids are presented. It was revealed that the tested microorganisms, such as S. aureus, S. epidermidis, S. agalactiae, E. faecalis, P. aeruginosa, S. pyogenes, K. pneumoniae and E. coli were mostly resistant to antimicrobials widely used in the clinical practice for treatment of infections of bacterial or fungal origin. It was registered that the carbon sorbent VNIITU-1 had no antibacterial activity against investigated microorganism strains. However, VNIITU-1 modified by the oligomers of lactic or glycolic acids demonstrated a pronounced antibacterial activity against most tested microorganisms.
Keywords: antimicrobial and antimycotic resistance, modified carbon sorbents
Received 14.03.2017
For citation:
Dolgikh V.T., Pjanova L.G., Likholobov V.A., Lavrenov A.V., Rudakov N.V., Chesnokova M.G., Sedanova A.V., Rusakov V.V., Korpachova O.V. Antibacterial and antimycotic properties of granularcarbon sorbents. Vestn. Ural. Med. Akad. Nauki = Jour. Ural Med. Acad. Science. 2017, no. 2, pp. 164–170. DOI: 10.22138/2500-0918-2017-14-2-164-170 (In Russ.)
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Authors
Vladimir T. Dolgikh
Omsk State Medical University
Dr. Sci. (Med.), Professor, Honored scientist of the Russian Federation, Head of
Department of Pathophysiology
Str. Lenin., 12, Omsk, 644099, Russian Federation
prof_dolgih@mai.ru
Lydia G. P’yanova
Institute of Hydrocarbon Processing
Dr. Sci. (Bio.), Senior Researcher
Str. Neftezavodskaya, 54, Omsk, 644040, Russian Federation
medugli@rambler.ru
Vladimir A. Likholobov
Institute of Hydrocarbon Processing
Dr. Sci.(Chem.), Professor, Corresponding Member of RAS, Scientific Head
Str. Neftezavodskaya, 54, Omsk, 644040, Russian Federation
val@ihcp.oscsbras.ru
Aleksandr V. Lavrenov
Institute of Hydrocarbon Processing
Cand.Sci.(Chem.), Director
Str. Neftezavodskaya, 54, Omsk, 644040, Russian Federation
val@ihcp.ru
Nikolay V. Rudakov
Omsk State Medical University
Dr. Sci. (Med.), Professor, Head of Department of Microbiology, Virology and Immunology
Str. Lenin., 12, Omsk, 644099, Russian Federation
nicolay@omsk-osma.ru
Marina G. Chesnokova
Omsk State Medical University
Dr. Sci. (Med.), Professor of Department of Microbiology, Virology and Immunology
Str. Lenin., 12, Omsk, 644099, Russian Federation
nicolay@omsk-osma.ru
Anna V. Sedanova
Institute of Hydrocarbon Processing
Cand.Sci.(Chem.), Senior Researcher
Str. Neftezavodskaya, 54, Omsk, 644040, Russian Federation
medugli@rambler.ru
Vladimir V. Rusakov
Omsk State Medical University
Dr. Sci. (Med.), Professor of Department of Pathophysiology
Str. Lenin., 12, Omsk, 644099, Russian Federation
vvrusakov@mail.ru
Olga V. Korpachova
Omsk State Medical University
Dr. Sci. (Med.), Professor of Department of Pathophysiology
Str. Lenin., 12, Omsk, 644099, Russian Federation
olgkor@mail.ru
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