Association of Adrenoreceptor Genes ADRB1 and ADRB2 Variants with Parameters of Heart Rate Variability in Men
DOI: 10.22138/2500-0918-2018-15-2-264-270
S.N. Kolomeichuk, D.A. Petrashova, V.V. Pozharskaya, R.V. Alekseev, A.Yu. Meigal, V.V. Megorskiy
Laboratory of Genetics, Institute of Biology of the Karelian Scientific Center of the Russian Academy of Sciences, Petrozavodsk, Russian Federatrion;
Research Center for Biomedical Problems of Human Adaptation in the Arctic FIC Kola Scientific Center of the Russian Academy of Sciences, Apatity, Russian Federation;
Petrozavodsk State University, Medical Institute, Petrozavodsk, Russian Federation
Abstract. Cardiovascular system is considered as an indicator of individual adaptive capabilities of the body. The main cause of sudden death of athletes are deviations in the work of the circulatory system. The search for genetic markers, significant for the functioning of the circulatory and muscular systems, determines the search for their correlation links with various phenotypes. The genes encoding beta-adrenergic receptors are proposed as such genes. The purpose of this study was to study the frequency distribution of alleles of adrenoreceptor ?1 gene ADRB1 and adrenoreceptor ?2 ADRB2 in men with different types of athletic load, as well as to identify the relationship of genotypes of these genetic markers with parameters of heart rate variability. Materials and methods. The study involved 60 people aged 18-31 with a sports experience of at least 5 years. At rest, athletes studied the characteristics of the heart rate and the functional state of the cardiovascular system. Using the PCR method in the group of athletes (wrestlers, skiers, athletes, all-men), the polymorphism of adrenoreceptor ?1 ADRB1 and adrenoreceptor ?2 ADRB2 genes was studied. Results. According to the results of the analysis, there was no association of polymorphic markers of ADRB1 and ADRB2 genes with cardiac activity in athletes.
Keywords: heart rate variability, genetic polymorphism, adrenergic receptors
Received 09.04.2018
For citation:
Kolomeichuk S.N., Petrashova D.A., Pozharskaya V.V., Alekseev R.V., Meigal A.Yu., Megorskiy V.V. Association of Adrenoreceptor Genes ADRB1 and ADRB2 Variants with Parameters of Heart Rate Variability in Men. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2018, Vol. 15, no. 2, pp. 264–270. DOI: 10.22138/2500-0918-2018-15-2-264-270 (In Russ)
REFERENCES
1. Morman D., Heller L. Fiziologija serdechno–sosudistoj sistemy. Piter, 2000, (In Russ.).
2. Dembo A.G., Zemcovskij Je.V. Sportivnaja kardiologija: Rukovodstvo dlja vrachej. Medicina, 1989, (In Russ.).
3. Fedotova A. G., Astratenkova I. V., Linde E. V., Ordzhonikidze Z. G., Ahmetov I.I. Kliniko–geneticheskie aspekty formirovaniya «patologicheskogo sportivnogo serdca» u vysokokvalificirovannyh sportsmenov. Vestnik sportivnoj nauki, 2009; (6): 32 – 37, (In Russ.).
4. Pohachevskij A.L. Funkcional'noe sostojanie i adaptacionnye rezervy organizma. Vestnik Novgorodskogo gosudarstvennogo universiteta, 2006, (In Russ.).
5. Aubert A.E. Heart rate variability in athletes. Sport Medicine, 2003.
6. Belova E.L. Vzaimosvjaz' pokazatelej ritma serdca i nekotoryh harakteristik trenirovochnyh i sorevnovatel'nyh nagruzok kvalificirovannyh lyzhnikov–gonshhikov. Vestnik sportivnoj nauki, 2009, (In Russ.).
7. Belocerkovskij Z.B. Jergometricheskie i kardiologicheskie kriterii fizicheskoj rabotosposobnosti u sportsmenov. Sovetskij sport, 2009, (In Russ.).
8. Iwai C, Akita H, Kanazawa K, et al: Arg389Gly polymorphism of the human beta 1-adrenergic receptor in patients with nonfatal acute myo cardial infarction. Am Heart J 146:106-109, 2003
9. Heckbert SR, Hindorff LA, Edwards KL, et al: beta2-Adrenergic receptor polymorphisms and risk of incident cardiovascular events in the el derly. Circulation 107:2021-2024, 2003
10. Covolo L, Gelatti U. Metra M. et al: Role of beta1- and beta2-adrenoceptor polymorphisms in heart failure: a case-control study. Eur Heart J 25:1534-1541. 2004. DOI: 10.1016/j.ehj.2004.06.015
11. Lanfear DE, Jones PG, Marsh S, et al: /32-Adrenergic receptor geno-type and survival among patients receiving -blocker therapy after an acute coronary syndrome. J Am Med Assoc 294:1526-1533, 2005
12. Timmermann B, Mo R, Luft EC. et al: Beta-2 adrenoceptor genetic variation is associated with genetic predisposition to essential hyper-tension: The Bergen Blood Pressure Study. Kidney Int 53:1461-1465, 1998
Authors
Sergey N. Kolomeichuk
Institute of Biology of the Karelian Scientific Center of the Russian Academy of Sciences
Cand. Sci. (Biol.), Senior Research Associate at Laboratory of Genetics
Russian Federation, 185910, Petrozavodsk, Pushkinskaya street, 11
sergey_kolomeychuk@rambler.ru
Dina A. Petrashova
Research Centre for Human Adaptation in the Arctic-Branch of the Federal Research Centre “Kola Science Centre of the Russian Academy of Sciences”
Cand. Sci. (Biol.), Scientific Secretary
Russian Federation, 184209 Murmansk region, Apatity, Fersmana str. 41a
petrashova@admksc.apatity.ru
Victoria V. Pozharskaya
Research Centre for Human Adaptation in the Arctic — Branch of the Federal Research Centre “Kola Science Centre of the Russian Academy of Sciences”
Cand. Sci. (Biol.), Research Associate
Russian Federation, 184209 Murmansk region, Apatity, Fersmana str. 41a
vika_pozharskaja@mail.ru
Roman V. Alekseev
Department of Human and Animal Physiology, Pathophysiology and Histology, Medical Institute, FGBOU Petrozavodsk State University
PhD student
Russian Federation, Republic of Karelia, 185035, Petrozavodsk, Krasnoarmeyskaya Str. 31
Alekseev.kafg@yandex.ru
Alexander Y. Meigal
Medical Institute, FGBOU Petrozavodsk State University
Professor at Department of Human and Animal Physiology, Pathophysiology and Histology
Russian Federation, Republic of Karelia, 185035, Petrozavodsk, Krasnoarmeyskaya Str. 31
meigal@mail.ru
Vladimir V. Megorsky
Research Centre for Human Adaptation in the Arctic — Branch of the Federal Research Centre “Kola Science Centre of the Russian Academy of Sciences”
Cand.Sci. (Med.), Head of Research Centre
Russian Federation, 184209 Murmansk region, Apatity, Fersmana str. 41a
megorsky@ya.ru
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