BIOELECTRIC IMPEDANCE OF THE BODY OF WISTAR RATS OF BOTH SEXES WITH A MONOCROTALINE MODEL OF PULMONARY ARTERIAL HYPERTENSION
DOI: 10.22138/2500-0918-2020-17-2-98-109
N.L. Kolomeyets, O.V. Syslonova, S.L. Smirnova, I.M. Roshchevskaya
Federal Research Centre “Komi Science Centre of the Ural Branch of the Russian Academy of Sciences”, Syktyvkar, Komi Republic, Russian Federation;
Federal State Budgetary Institution “Research Zakusov Institute Of Pharmacology”, Moscow
Abstract. The aim of the work was to study the bioelectric impedance of the body in rats of both genders with monocrotaline-induced pulmonary hypertension. Materials and methods. Multi-frequency bioimpedance studies of the body of rats of both genders were carried out one month after the administration of monocrotaline (dose of 60 mg/kg, subcutaneously). Results. Hypertrophy of the right ventricle of the heart was revealed in animals with experimentally induced pulmonary hypertension, with a significantly greater thickness of the free wall of the right ventricle in males compared to females. Significant influence of the interaction of the gender factor and the effect of monocrotaline on the indicators of the bioelectric impedance of the body (amplitude, ratio of resistances at low and high current frequencies) was shown using the method of analysis of variance. The body bioelectric impedance amplitudes, normalized to body length, were significantly lower in the male rats and higher in the female rats with experimental pulmonary hypertension compared to the control animals of the same gender. In the female rats with the monocrotaline model of pulmonary hypertension, the ratio of the amplitudes of the bioelectric impedance of the body at low and high current frequencies was significantly lower than in the control animals. Conclusion. Changes in the body resistance of the rats with pulmonary hypertension indicate an inflammatory process. Gender differences in the changes in the bioelectrical impedance of the body indicate a more severe manifestation of pulmonary hypertension in the males.
Keywords: monocrotaline model of pulmonary hypertension, bioelectrical impedance of the body
Received 16.03.2020
For citation:
Kolomeyets N.L., Syslonova O.V., Smirnova S.L., Roshchevskaya I.M. Bioelectric impedance of the body of wistar rats of both sexes with a monocrotaline model of pulmonary arterial hypertension. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2020, Vol. 17, no. 2, pp. 98–109. URL: http://vestnikural.ru/article/1116. DOI: 10.22138/2500-0918-2020-17-2-98-109 (In Russ)
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Authors
Natalia L. Kolomeyets
Federal Research Centre “Komi Science Centre of the Ural Branch of the Russian Academy of Sciences”
Cand. Sci. (Physics and Mathematics), Researcher of the departure of Comparative Cardiology
24, Kommunisticheskaya str., Syktyvkar, Komi Republic, Russian Federation, 167982
nat.kolomeyets@gmail.com
Olga V. Suslonova
Federal Research Centre “Komi Science Centre of the Ural Branch of the Russian Academy of Sciences”
Researcher of the departure of Comparative Cardiology
24, Kommunisticheskaya str., Syktyvkar, Komi Republic, Russian Federation, 167982
evgeniu2006@inbox.ru
Svetlana L. Smirnova
Federal Research Centre “Komi Science Centre of the Ural Branch of the Russian Academy of Sciences”
Cand. Sci. (Bio.), Head of the departure of Comparative Cardiology
24, Kommunisticheskaya str., Syktyvkar, Komi Republic, Russian Federation, 167982
smirnova.sl@mail.ru
Irina M. Roschevskaya
Federal State Budgetary Institution “Research Zakusov Institute Of Pharmacology”, Moscow
Corresponding Member RAS, Chief Researcher
8, Baltiyskaya st., Moscow, 125315, Russian Federation
compcard@mail.ru