BIOCHEMICAL ASPECTS OF LIPID PEROXIDATION. MODERN METHODS OF DIAGNOSTICS OF CELL MEMBRANE DAMAGE
DOI: 10.22138/2500-0918-2021-18-2-78-84
Yu.V. Boldyreva¹, Yu.M. Mardanov¹, I.A. Lebedev¹,
M.N. Alyokhina², E.V. Zakharchuk¹, S.V. Adamchuk¹
¹ Tyumen State Medical University, Tyumen, Russian Federation;
² GAU TO City polyclinic No. 8, Tyumen, Russian Federation
Abstract. The fundamentals of the biochemical processes underlying the damage of cell membranes are characterized, and modern methods of diagnosing lipid peroxidation (POL) are considered. POL is a chain reaction that provides an expanded reproduction of free radicals (reactive oxygen species), which initiate the further spread of POL. Reactive oxygen species can take an electron (s) away from molecules and, thereby, start a cascade of free radical oxidation reactions, as a result of which the substance becomes unable to perform its functions, because first of all, the oxidation of cell lipids occurs, which leads to damage to the cell membrane and cell death as a whole. High activity of sex is characteristic of many diseases. Therefore, it is important to be able to diagnose the level of oxidative stress in the body. Oxidative stress is expressed in the formation of numerous products that differ in chemical structure, lifetime, toxicity and biological activity. The analysis of POL products is of interest for assessing the level of oxidative stress in the body, for studying the toxic, metabolic and regulatory effects of this process on the body, as well as for the diagnosis of certain diseases.
Keywords: lipid peroxidation, phospholipids, diagnostic methods, antioxidant protection, cell membranes
There is no conflict of interest.
Contact details of the corresponding author:
Ilya A. Lebedev
lebedef@inbox.ru
Received 03.06.2021
For citation:
Boldyreva Yu.V., Mardanov Yu.M., Lebedev I.A., Alyokhina M.N., Zakharchuk E.V.,
Adamchuk S.V. Biochemical Aspects of Lipid Peroxidation. Modern Methods of Diagnostics of Cell Membrane Damage. [Online] Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2021, Vol. 18, no. 2, pp. 78–84. DOI: 10.22138/2500-0918-2021-18-2-78-84 (In Russ)
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Authors
Yulia V. Boldyreva
Tyumen State Medical University
PhD
54 Odesskaya street Tyumen Russian Federation 625023
ORCID: 0000-0002-3276-7615
eLibrary SPIN: 1449-4485
tgma.06@mail.ru
Yunus M. Mardanov
Tyumen State Medical University
Student of the Faculty of Medicine
54 Odesskaya street Tyumen Russian Federation 625023
Ilya A. Lebedev
Tyumen State Medical University
MD
54 Odesskaya street Tyumen Russian Federation 625023
ORCID: 0000-0001-5405-7182
eLibrary SPIN: 6155-1308
lebedef@inbox.ru
Maria N. Alyokhina
City Polyclinic No. 8, Tyumen
General practitioner
10B Vatutina street Tyumen Russian Federation 625031
Ekaterina V. Zakharchuk
Tyumen State Medical University
Assistant
54 Odesskaya street Tyumen Russian Federation 625023
ORCID: 0000-0002-1317-5219
Sofia V. Adamchuk
Tyumen State Medical University
Student of the Faculty of Pediatrics
54 Odesskaya street Tyumen Russian Federation 625023
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)