Deficiency of vitamin D and parameters of oxidative stress in young people under the Arctic Region

DOI: 10.22138/2500-0918-2019-16-2-147-152

S.I. Malyavskaya, G.N. Kostrova, А.V. Lebedev

Northern State Medical University, Arkhangelsk, Russian Federation

Abstract. Vitamin D deficiency is an important issue in modern medicine. The literature shows the effect of vitamin D on the processes of oxidative stress and inflammation, atrogenesis, and chronic non-infectious diseases. The provision of vitamin D is important when living in the Arctic region due to the high probability of the development of oxidative disorders. Objective: to evaluate the effect of the level of 25(OH)D on the parameters of oxidative stress. Materials and methods. Persons of the youthful age of Arkhangelsk were examined: the level of 25-hydroxyvitamin D, the level of highly sensitive C-reactive peripheral blood protein, the level of total peroxide (SPP), the total antioxidant ability (OSA) of the blood by immunoassay were analyzed. Results: Vitamin D deficiency was found in 28 people (23%), deficiency was found in 42 people (34%) and severe deficiency in 13 people (11%) of this sample. The overwhelming majority — 82 people (66%) — had C-reactive protein levels of less than 1 mg/l, revealed low overall antioxidant activity, a lower concentration of CRP at a normal level of 25 (OH)D relative to the group with vitamin D deficiency. Conclusions: This study demonstrated the effect of level 25 (OH) D on parameters of oxidative stress and inflammation.

Keywords: vitamin D, 25(OH)D, oxidative stress, highly sensitive C-reactive protein, Arctic region

Received 15.04.2019.

For citation:
Malyavskaya S.I., Kostrova G.N., Lebedev A.V. Deficiency of vitamin D and parameters of oxidative stress in young people under the Arctic Region. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2019, Vol. 16, no. 2, pp. 147–152. DOI: 10.22138/2500-0918-2019-16-2-147-152 (In Russ)

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Authors
Svetlana I. Malyavskaya
Dr. Sci. (Med.), Professor, Vice-Rector for Science and Innovation
malyavskaya@yandex.ru

Galina N. Kostrova
Cand. Sci. (Med.), Associate Professor, Associate Professor of the Department of Normal Physiology
kostrovagn@yandex.ru.

Andrey V. Lebedev
Cand. Sci. (Med), Associate Professor, Associate Professor of the Department of Pathological Physiology
andruleb@yandex.ru

Northern State Medical University
Troitsky av. 51, Arkhangelsk, Russian Federation, 163001

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)