Differentiated approach towards appointment of metoprolol and acridilol in acute coronary syndrome and a comparative evaluation of their effect on brain natriuretic peptide
Ibragimov M.S., Andreev A.N., Milashchenko A.I., Kozlov P.A.
Abstract. Individualization of therapy as part of evidence-based medicine is a very important aspect in the treatment of acute coronary syndrome (ACS). ACS treatment should be started in the intensive care unit; treatment efficacy directly correlates with prognostic indicators. The aim of this study is to determine the effect of different beta-blockers (βAB) (metoprolol and carvedilol) on the course of ACS and observing the dynamics of brain natriuretic peptide (BNP). The study included 156 patients with ACS. At the first stage to study the effect of different doses of intravenous metoprolol on hemodynamics and BNP in patients with ACS. In the second stage the data obtained in the application of metoprolol were retrospectively compared with the results of the data obtained during therapy with acridilol in patients with ACS. In the comparative analysis of indicators of BNP we have not received a statistically significant difference between the groups. Revealed that some patients with ACS to achieve the desired hemodynamic and “clinical peace” enough small and medium doses βAB.
Keywords: ACS, betablockers, metoprolol, akridilol, hemodynamics, BNP
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Authors
Ibragimov Mubariz S.
Municipal budgetary central clinical city hospital number 24, Department of Intensive Care, Yekaterinburg, Russian Federation
PhD, Assistant Professor of Hospital TherapyDepartment
Russian Federation, Yekaterinburg, Rizhskij 16
ibragimovmd@yandex.ru
Andreev Arkadij N.
MD, Professor, Head of Hospital Therapy Department
an-andreyev@mail.ru
MilashchenkoAngeliya I.
The second-year resident of Hospital TherapyDepartment
milashchenko-ai@yandex.ru
KozlovPavel A.
Postgraduate of Hospital TherapyDepartment
axe_p@mail.ru
Ural State Medical University
Russian Federation, Yekaterinburg, Repina 3
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