DYNAMICS, INFORMATIVITY AND PREDICTIVE VALUE OF BODY TEMPERATURE AT SULFUR MUSTARD INTOXICATION IN RATS

DOI: 10.22138/2500-0918-2022-19-5-492-501

S.P. Sidorov¹, A.A. Sergeev¹, K.A. Bulka², S.V. Chepur¹,
A.A. Kuz`min¹, A.I. Shiryaeva¹

¹State Scientific Test Research Institute of Military Medicine, Ministry of Defense of the Russian Federation, Saint Petersburg, Russian Federation;

²Military Medical Academy of S. M. Kirova, Ministry of Defense of the Russian Federation, Saint Petersburg, Russian Fedferation

Abstract. Introduction. In experimental toxicology, the selection of criteria characterizing the toxicological process play an important role in evaluating the effectiveness of the means of prevention and treatment of intoxication. Aim of the study: study of the dynamics, informativity and prognostic significance of rectal temperature at sulfur mustard intoxication in rats. Results of the study. The results showed that intramuscular injection of sulfuric mustard in rats in the range of doses from minimally lethal to absolutely lethal is accompanied by a dose-dependent decrease in rectal temperature at 3-days of intoxication. In the studied sample, the dividing capacity (AUC) of the rectal temperature index at the intoxication peak (3-d day) for mortality was 0,94 (95 % CI 0,8–0,91), which corresponds to excellent predictive ability. The sensitivity and specificity parameters for rectal temperature were 0,86 (95 % CI 0,8–0,91) and 0,90 (95 % CI 0,83–0,95), respectively. Conclusions. Rectal temperature values reflect the dynamics and severity of sulfur mustard intoxication in rats. This criterion has a high informative and predictive value in relation to the death and can be reasonably included in the program of evaluation of the effectiveness of the developed means of prevention and treatment of sulfur mustard

Keywords: sulfur mustard, acute toxicity, body mass, rectal temperature, ROC-analysis

There is no conflict of interest.
Contact details of the corresponding author:
Sergey P. Sidorov
sidorovsp@gmail.com
Received 28.04.2022
For citation:
Sidorov S.P., Sergeev A.A., Bulka K.A., Chepur S.V., Kuz`min A.A., Shiryaeva A.I. Dynamics, informativity and predictive value of body temperature at sulfur mustard intoxication in rats. [Online] Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2022, Vol. 19, no. 5, pp. 492–501. DOI: 10.22138/2500-0918-2022-19-5-492-501 (In Russ)

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Auhtors
Sergey P. Sidorov
State Scientific Test Research Institute of Military Medicine, Ministry of Defense of the Russian Federation
Candidate of medical science, head of research department
4 Lesoparkovaja street Saint Petersburg Russian Federation 195043
sidorovsp@gmail.com

Anatoly A. Sergeev
State Scientific Test Research Institute of Military Medicine, Ministry of Defense of the Russian Federation
Candidate of biological science, senior research scientist of research department
4 Lesoparkovaja street Saint Petersburg Russian Federation 195043
gniiivm_2@mil.ru

Kirill A. Bulka
Military Medical Academy of S. M. Kirova, Ministry of Defense of the Russian Federation
Candidate of medical science, department of hospital therapy
6 Akademica Lebedeva street Saint Petersburg Russian Federation 194044
vmeda-nio@mil.ru

Sergey V. Chepur
State Scientific Test Research Institute of Military Medicine, Ministry of Defense of the Russian Federation
Doctor of medical science, professor, director of the State Scientific Test Research Institute of Military Medicine
4 Lesoparkovaja street Saint Petersburg Russian Federation 195043
gniiivm_2@mil.ru

Andrey A. Kuzmin
State Scientific Test Research Institute of Military Medicine, Ministry of Defense of the Russian Federation
Doctor of medical science, senior research officer
4 Lesoparkovaja street Saint Petersburg Russian Federation 195043
gniiivm_2@mil.ru

Alyona I. Shiryaeva
State Scientific Test Research Institute of Military Medicine, Ministry of Defense of the Russian Federation
Research assistant of research
4 Lesoparkovaja street Saint Petersburg Russian Federation 195043
gniiivm_2@mil.ru