Vegetable flavonoids accumulation dynamics and their potential for the prevention of stress of the population of the Kola Arctic
DOI: 10.22138/2500-0918-2019-16-2-284-289
A.V. Korovkina
Laboratory for medical and biological technologies, the Federal Research Centre “Kola Science Centre of the Russian Academy of Sciences”,Apatity, Murmansk region, Russian Federation
Abstract. Introduction. At present, the oxidative stress (OS) is considered to be an important pathogenic factor in more than 200 diseases, which is explained by the versatility and the key role of the redox reactions (RDR) in the man’s organism. The necessity of new health-protecting technologies, and the necessity of import substitution in the pharmacological field of the region call for the necessity of search of new ecologically friendly and effective drugs. Of a significant potential here is a group of bioflavonoids demonstrating both anti- and prohoidant activity, which testifies a complicated character of the free radical oxidation regulation (FRO) under the extreme conditions. This determines the necessity to use natural complexes of adaptogenic compounds synthesized by plants in an unfavourable habitat in order to make the human’s organism stronger because it is subjected to the influence of the similar factors. The aim of the study was to determine of the quantitative value and dynamics of the accumulation of flavonoids in the tissues of various organs of plants of the Polygonum weirichii (Poligonum weyrichii Fr. Schmidt.) during the growing season. Materials and methods. The material was the leaves of the upper and middle tiers of shoots, inflorescences and rhizomes of wild plants of the Polygonum weirichii (Poligonum weyrichii Fr. Schmidt. family Poligonaceae), growing on the protected territory of the Polar Alpine Botanical Garden-Institute. N.A. Avrorina, located near the city of Kirovsk. The concentration of total flavonoids in the filtrate was determined by the optical absorption of their complex with aluminum chloride. Conclusions. The data obtained testify the fact that the highest content of these compounds is found in the leaves and inflorescences at the beginning or in the second half of the vegetation period. Discussed in the paper are the possibilities and potential of the use of the Polygonum weirichii plants as the basic culture in the regional production of adaptogenic drugs.
Keywords: flavonoids, accumulation dynamics, oxidative stress, free radical oxidation
Received 19.04.2019.
For citation:
Korovkina A.V. Vegetable flavonoids accumulation dynamics and their potential for the prevention of stress of the population of the Kola Arctic. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2019, Vol. 16, no. 2, pp. 284–289. DOI: 10.22138/2500-0918-2019-16-2-284-289 (In Russ)
REFERENCES
1. Integrated climate strategies for sustainable development of the Russian Arctic regions in the context of climate change (a model example of the Murmansk region). Moscow: Programma razvitiya OON v Rossii, Rossijskij regional'nyj ehkologicheskij centr; 2009. (in Russ).
2. Zhirov V.K. ,Golubeva E.I. ,Govorova A.F., Xaitbaev A.X. Structural and functional changes of vegetation in the conditions of technogenic pollution in the Far North. Moscow: Nauka; 2007. (in Russ).
3. Hasnulin V.I. ,Hasnulin P.V. Ecologically caused Northern stress (polar stress syndrome). Problemy` zdravooxraneniya i social`nogo razvitiya arkticheskoj zony` Rossii. 2011. pp 69-82. (in Russ).
4. Zhirov V.K., Kuz`min A.V., Rudenko S.M., Kostyuk V.I., Kashulin P.A., Zhiboedov P.M. Adaptation and age variability of plants in the North. Apatites. KNCz RAN.2001.
5. Men`shhikova E.B., Zenkov N.K., Lankin V.Z., Bondar`I.A., Trufakin V.A. Oxidative stress: Pathological conditions and diseases. Novosibirsk: Artra; 2008. (in Russ).
6. Donczov V.I., Krut`ko V.N., Mrikaev B.M., Uxanov S.V. Active forms of oxygen as a system: value in physiology, pathology and natural aging. Tr. ISA RAN. 2006; 19, pp. 50-69. (in Russ).
7. Youngyo K., Youjin Je .Flavonoid intake and mortality from cardiovascular disease and all causes: A meta-analysis of prospective cohort studies.2017. Vol 20. pp 68-77. DOI 10.1016/j.clnesp.2017.03.004.
8. Khodos M.Ya., Kazakov Ya.E., Vidrevich M.B., Brainina Kh.Z. Oxidative stress and its role in pathogenesis.Vestn. Ural. Med. Akad. Nauki. Journal of Ural Medical Academic Science. 2017, Vol. 14, no. 4, pp. 381–398. DOI:10.22138/2500-0918-2017-14-4-381-398 (in Russ).
9. Luczkij M.A., Kuksova T.V., Smelyanecz M.A., Lushnikova Yu.P. Free radical oxidation of lipids and proteins is a universal process of vital activity of the organism.Uspexi sovremennogo estestvoznaniya,no.12,2014. (in Russ).
10. Kurkina A.V. Flavonoids of plants of the Pharmacopoeia. Samara: OOO Ofort 2012. (in Russ).
11. Luis A. del Rio. ROS and RNS in plant physiology: an overview. Journal of Experimental Botany. 2015. vol 10. pp. 2828-2837. DOI 10.1093/jxb/erv099.
12. Panche A.N., Diwan A. D.Chandra S.R. Flavonoids: an overview. Journal of Nutritional Science. 2016, vol. 5, DOI 10.1017/jns.2016.41.
13. Taraxovskij Yu.S., Kim Yu.A., Abdrasilov B.S., Muzafarov E.N. Flavonoids: biochemistry, Biophysics, medicine. Pushchino: Sunchrobook, 2013. (in Russ).
14. Statistical yearbook. Murmansk: Murmanskstat 2016. (in Russ).
15. Zhang, H., Tsao, R. Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects. Current Opinion in Food Science. 2016. Vol. 8. pp. 33-42. DOI 10.1016/j.cofs.2016.02.002.
16. Efremov V.V. Productivity Poligonum weyrichii Fr. Schmidt in field fodder production. Aktual`ny`e voprosy` sovershenstvovaniya texnologii proizvodstva i pererabotki produkcii sel`skogo xozyajstva. 2018. No. 20 pp. 30-32. (in Russ).
17. Zhiboedov P.M. The study of endogenous compounds, modifying free-radical oxidation. Apatity, 1991. (In Russ).
18. State Standard 177768-90. Drugs. Packaging, marking, transportation and storage. Moscow: Standartinform Publ., 2003. (In Russ).
19. Belikov V.V., Shrajber M.S. Methods of analysis of flavonoid compounds. Farmaciya.1:66-73, 1970. (In Russ).
20. Vy`sochina G.I., Shaldaeva T.M., Koczupij O.V., Xramova E.P. Marie white flavonoids (Chenopodium album L.), native to Siberia. Ximiya rastitel`nogo sy`r`ya.2009. No. 4, pp. 107-112. (In Russ).
21. Krenke I.P. Theory of cyclic aging and rejuvenation of plants and its practical application. OGIZ Sel`xozgiz. 1940. (In Russ).
Author
Anna V. Korovkina
Laboratory for medical and biological technologies, the Federal Research Centre “Kola Science Centre of the Russian Academy of Sciences”
Junior research assistant
Akademgorodok, 41a, Apatity, Russian Federation 184209
dokktorr@list.ru
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