Electrophoretic Transfer of Nanocluster Polyoxometalate Mo72Fe30 Associates Through the Skin Membrane
Tonkushina M.O., Gagarin I.D., Grzhegorzhevskii К.V., Ostroushko A.A.
FSBIS Institute of Immunology and Physiology, Ural Branch, RAS; FSAEI HPE Ural Federal University named after the first President of Russia B.N. Yeltsin,
Yekaterinburg, Russian Federation
Abstract. The nanocluster polyoxometalate Mo72Fe30 is interesting as nanocapsule for targeted delivery of drugs in the body. In solution Mo72Fe30 is charged, which creates the possibility of its introduction by electrophoresis. In this work the electrophoretic transfer of its associates with biocompatible polymer – polyvinylpyrrolidone, which is necessary to «disguise» nanocluster from the reaction of the immune system, and cations of lanthanum, which can be used as ion tags to monitor the movement of nanocluster in the tissues of the body was made. We calculated the coefficient of diffusion of associates.
Keywords: targeted delivery, nanocapsule, polyoxometalate, electrophoresis
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Authors
Tonkushina Margarita O., e-mail: rita-zar@yandex.ru
FSBIS Institute of Immunology and Physiology, Ural Branch, RAS
junior research worker
Postal address: 620002, 106 Pervomayskaya street, Yekaterinburg, Russian Federation
Gagarin Ilya D., e-mail: idgagarin@gmail.com
Grzhegorzhevskii Kirill V., e-mail: kirillica5@mail.ru
FSAEI HPE Ural Federal University named after the first President of Russia B.N. Yeltsin, doctor of chemistry, professor, head of division
Postal address: 620002, 19 Mira street, Yekaterinburg, Russian Federation
Ostroushko Alexander A., e-mail: alexander.ostroushko@urfu.ru
FSAEI HPE Ural Federal University named after the first President of Russia B.N. Yeltsin, doctor of chemistry, professor, head of division
Postal address: 620002, 19 Mira street, Yekaterinburg, Russian Federation