Endogenous Tissue Regeneration Thymus with Congenital Hypoxia Cause Fetal Developmenta Disorders Heart

Loginova N. P., Chetvertykh V. A., Semchenko V. V.

Acad. E. A Wagner Perm State Medical Academy” Ministry of Health and Social Development, Perm, Russian Federation;
Institute of Veterinary Medicine and Biotechnology P. A. Stolypin Omsk State Agrarian University, Omsk, Russian Federation

Abstract.

With the help of morphological and immunohistochemical methods and the structural features of the thymus in the chest during postnatal ontogenesis in children (n = 77) under conditions of hypoxia-induced embryonic developmental disorders of the heart, of varying difficulty. It is found that changes in the structure of the thymus depends on the complexity of heart defect, which determines the degree of hypoxia. In children with complex congenital (blue) recorded a decrease in the expression of retikuloepiteliotsitahPanCK, accompanied by a breach of the architectonics of epithelial stroma. On semithin sections showed signs of degenerative changes in the cells of the stroma, which resulted in the devastation of alopecia cortex lobules. Against this backdrop, intensified fibroblast cells differon with positive expression of monoclonal antibodies to CD 34 and vimentin. Observed active angiogenesis processes involving fibroblast cells differon. Number and activity of poorly differentiated fibroblasts correlated with the severity of hypoxia.

Keywords:

thymus, the reticular epithelial cells, endogenous regeneration, progenitor cells, innate hypoxia

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Authors
Loginova Nataliya P. 
Medical University «Perm State Medical Academy. ak. EA Wagner's «Medical University, Perm
MD, Associate Professor of Histology, Cytology and Embryology
Russian Federation, Perm, 614000, st. The Peter and Paul 26
Chetvertnyh Viktor A.
Medical University «Perm State Medical Academy. ak. EA Wagner's «Medical University, Perm
MD, Professor, Head of the Department of Histology, Cytology and Embryology
Russian Federation, Perm, 614000, st. The Peter and Paul 26
Semchenko Valeriy V.
Institute of Veterinary Medicine and Biotechnology Institute of Veterinary Medicine and Biotechnology P.A. Stolypin Omsk State Agrarian University, Omsk
MD, professor, head of the course of Cytology, Histology and Embryology
Scientific director of the histological laboratory with electron microscopy
Russian Federation, 644122, Omsk, ul. October, d.92