ENDOMETRIOSIS: ISSUES OF PATHOGENESIS
DOI: 10.22138/2500-0918-2021-18-3-239-252
E.V. Kudryavtseva¹, T.A. Oboskalova¹, A.V. Vorontsona¹, A.V. Chizhova²
¹Ural State Medical university, Yekaterinburg, Russian Federation;
²State Autonomous Healthcare Institution of the Sverdlovsk Region «State Clinical Hospital No. 14», Yekaterinburg, Russian Federation
Abstract. Endometriosis is one of the most common gynecological diseases. But despite the fact that this pathology has been studied for many years, a consensus regarding the etiopathogenesis of this disease has not yet been reached. This literature review discusses several of the most significant theories regarding the origin of such a mysterious disease as endometriosis. Most of the data obtained indicate that endometriosis is a multifactorial pathology, with the participation of many genetic and environmental influences. At the same time, it is likely that one etiopathogenetic model of endometriosis, even including many genetic and epigenetic parameters, is not enough, since endometriosis is a heterogeneous disease with significant differences in the forms and clinical manifestations, as well as the initial background processes on which it develops.
Keywords: endometriosis, genetic polymorphism, cytokines, mesenchymal stem cells, retrograde menstruation
There is no conflict of interest.
Contact details of the corresponding author:
Elena V. Kudryavtseva
elenavladpopova@yandex.ru
Received 02.09.2021
For citation:
Kudryavtseva E.V., Oboskalova T.A., Vorontsona A.V., Chizhova A.V. Endometriosis: issues of pathogenesis. [Online] Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2021, Vol. 18, no. 3, pp. 239–252. DOI: 10.22138/2500-0918-2021-18-3-239-252 (In Russ)
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Authors
Elena V. Kudryavtseva
Ural State Medical University
PhD, MD, assistant professor
3 Repin st. Yekaterinburg Russian Federation, 620028
elenavladpopova@yandex.ru
Tatyana A. Oboskalova
Ural State Medical University
PhD, MD, professor, Head of the Department of Obstetrics and Gynecology
3 Repin st. Yekaterinburg Russian Federation, 620028
oboskalova.tat@yandex.ru
AnnaV. Vorontsova
Ural State Medical University
PhD, MD, assistant professor
3 Repin st. Yekaterinburg Russian Federation, 620028
a_valerevna@mail.ru
Anna V. Chizhova
State Autonomous Healthcare Institution of the Sverdlovsk Region «State Clinical Hospital No. 14»
MD, Obstetrician-gynecologist
15A 22 Party Congress str. Yekaterinburg Russian Federation 620039
annabobina17@mail.ru
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)