PHYSIOLOGY AND PATHOPHYSIOLOGY OF THE ARTERIAL BED IN THE BACKGROUND OF SEPARATE COMORBID STATES IN PEOPLE LIVING IN THE NORTH

DOI: 10.22138/2500-0918-2019-16-1-10-21

A.Yu. Afineevskaya

Surgut State Pedagogical University, Surgut, Russion Federation

Abstract. Introduction. As a multifocal disease atherosclerosis is the basic predictor of development of pathologies of cardiovascular system. Analyzing inflammation, dyslipidemia and other predictors of atherosclerosis that effect vessel wall rigidity modern researchers are studying not only existing mechanism of forming of that condition – endothelial dysfunction – but also a new conception – “from the outside to the inside” emphasizing the role of adventitia and perivascular adipose tissue. Objective: To analyze data from scientific sources on the state of the cardiovascular system and comorbid conditions under the influence of the conditions of the Middle Ob region. Materials and methods. The review analysis is based on data from the main scientometric databases — Scopus, Pub Med, RISC, and others. Studied 29 domestic articles and more than 30 modern foreign sources, mainly in the last 5 years. The author's vision of the questions posed in the article is formulated. Findings. The role of comorbid conditions of early atherosclerosis development is reliably well-known and represents a trigger factor. Though the questions of impact of climatic conditions of the North on the dynamics of these processes are practically unillustrated today. It’s also important to take into consideration the influence of biorhythm synchronizers in the conditions of the Far North that are able to form hormone metabolic and immunological depressions in the process of deadaptation. Studying the condition of cardiovascular system under the influence of the above-stated factor by way of example of the population of the middle Priob'ye will help to answer many questions of that range of problems.

Keywords: atherosclerosis, dyslipidemia, endothelial dysfunction, comorbidity, connective tissue dysplasia

There is no conflict of interest.

Contact details of the corresponding author:
Anna Yu. Afineevskaya
afineevskayaanna@gmail.com

Received 11.03.2019

For citation:
Afineevskaya A.Yu. Physiology and pathophysiology of the arterial bed in the background of separate comorbid states in people living in the North. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2019, Vol. 16, no. 1, pp. 10–21. DOI: 10.22138/2500-0918-2019-16-1-10-21 (In Russ)

REFERENCES
1. Rodríguez-Saldaña J., Rodriguez-Flores M., Cantú-Brito C., Aguirre-Garcia J. A Pathological Study of the Epidemiology of Atherosclerosis in Mexico City.
Cardiology Research and Practice. 2014; 8: 2014.
2. Samson S., Mundkur L., Vijay V.K. Immune Response to Lipoproteins in Atherosclerosis. Cholesterol. 2012; 1-12.
3. Avaliani V.M., Chernov I.I., Shonbin A.N., Tungusov D.S. Rasprostranennost' mul'tifokal'nogo ateroskleroza na Yevropeyskom severe. Ekologiya cheloveka. 2005; 7: 22-27.( in Russ)
4. Aziz M., Yadav K.S. Pathogenesis of Atherosclerosis. Med Clin Rev. 2016; 2 (3:22): 1-6. 5. Kovacic S., Bakran Stroke M. Genetic Susceptibility to Atherosclerosis. Research and Treatment. 2012; 5: 2012.
6. Mozaffarian D., Benjamin E.J., Go A.S. Heart disease and stroke statistics-2016 update: a report from the American Heart Association. Circulation. 2016; 133 (4): 38–360.
7. Sobenin I.A., Salonen J.T., Zhelankin A.V., Melnichenko A.A., Kaikkonen J., Bobryshev Y.V. et al. Low Density Lipoprotein-Containing Circulating Immune Complexes: Role in Atherosclerosis and Diagnostic Value. BioMed Research International. 2014; 1-7. 
8. Levshakova A.V., Domashenko M.A. Ostroye narusheniye mozgovogo krovoobrashcheniya: diagnosticheskiye i organizatsionnyye aspekty. Radiologiya-praktika. 2014; 1: 48-57. ( in Russ)
9. Argunov V.A. Vozrastnaya dinamika ateroskleroza aorty i koronarnykh arteriy u muzhchin g.Yakutska i yego evolyutsiya za 40 let. Ateroskleroz. 2010; 6 (1): 20-25. ( in Russ)
10. Kuranov A.A., Baleyev M.S., Mitrofanova N.N., Mel'nikov V.L. Nekotoryye aspekty ateroskleroza i faktory riska razvitiya serdechno-sosudistykh zabolevaniy. Fundamental'nyye issledovaniya. 2014; 10-6: 1234-1238. ( in Russ)
11. Weber C., Noels H. Atherosclerosis: current pathogenesis and therapeutic options. Nature Medicine. 2011;17 (11): 1410–1422

12. Shah P., Bajaj S., Virk H., Bikkina M., Shamoon F. Rapid Progression of Coronary Atherosclerosis: A Review. Thrombosis. 2015; 6: 2015.33. Popova Ye.A., Andronov S.V., Popov A.I. Izmeneniya fiziologicheskikh pokazateley zhiteley Kraynego Severa pod vliyaniyem astronomicheskikh vozmushcheniy. Vestnik Chelyabinskogo gosudarstvennogo universiteta. 2014; 13 (342): 74-78. ( in Russ)
34. Boronoyev V.V. Iyerarkhiya bioritmov v organizme cheloveka. Mezhdunarodnyy zhurnal prikladnykh i fundamental'nykh issledovaniy. 2015; 11-1: 37-40. ( in Russ)
35. Sobolevskaya I.S., Myadelets O.D., Pashinskaya Ye.S. Tsirkadnyye ritmy i metabolizm lipidov v zhivotnykh kletkakh. Chast' II. Vliyaniye tsirkadnykh ritmov na obshchiy pokrov i zhirovuyu tkan'. Desinkhronoz i lipidnyy obmen. Vkstsi natsyyanal'nay akademii navuk Belarusi. Seryya biyalagichnykh navuk. 2017; 3: 104-116. ( in Russ)
36. Popova Ye.A., Andronov S.V., Popov A.I. Izmeneniya fiziologicheskikh pokazateley zhiteley Kraynego Severa pod vliyaniyem astronomicheskikh vozmushcheniy. Vestnik Chelyabinskogo gosudarstvennogo universiteta. 2014; 13 (342): 74-78. ( in Russ)
37. Sevost'yanova Ye.V. Osobennosti lipidnogo i uglevodnogo metabolizma cheloveka na Severe. Byulleten' sibirskoy meditsiny. 2013; 12 (1): 93-100. ( in Russ)
38. Klimova T.M., Fedorova V.I., Baltakhinova M.Ye., Krivoshapkina V.G. Soderzhaniye kholesterina i risk ateroskleroza u sel'skogo korennogo naseleniya respubliki Sakha (Yakutiya). Ekologiya cheloveka. 2014; 4: 22-27. ( in Russ)
39. Bichkayeva F.A., Kokoyev T.I., Dzhioyeva TS.G., Dzhabiyeva Z.A., Volkova N.I., Tpet'yakova T.V i dr. Soderzhaniye v syvorotke krovi apolipoproteinov A, V i parametry obmena lipidov u zhiteley pripolyarnykh regionov Severa i yuzhnykh regionov Kavkaza. Klinicheskaya laboratornaya diagnostika. 2013; 1: 25-27. ( in Russ)
40. Nagibovich O.A., Ukhovskiy D.M., Zhekalov A.N., Tkachuk N.A., Arzhavkina L.G., Bogdanova Ye.G. i dr. Mekhanizmy gipoksii v Arkticheskoy zone Rossiyskoy Federatsii. Vestnik Rossiyskoy voyenno-meditsinskoy akademii. 2016; 2 (54): 202-205. ( in Russ)
41. Ivanova E.A., Orekhov A.N. Monocyte Activation in Immunopathology: Cellular Test for Development of Diagnostics and Therapy. Journal of Immunology Research. 1-9. 2016.
42. Nenenko N.D. Osobennosti immunnogo statusa korennogo i prishlogo naseleniya KHMAO-Yugry. Mezhdunarodnyy zhurnal prikladnykh i fundamental'nykh issledovaniy. 2015; 12-9: 1644-1645. ( in Russ)
43. Drozhzhin Ye.V., Lushchenko I.V., Zor'kin A.A. Dinamika izmereniy vnutriserdechnoy gemodinamiki u bol'nykh s sindromom kriticheskoy ishemii i IBS pri mnogourovnevykh arterial'nykh okklyuziyakh v zavisimosti ot osobennostey kompleksnoy terapii. Vestn. novykh med. tekhnologiy. 2015; 9 (2): 11. ( in Russ)
44. Meune C., Touzé E., Trinquart L., Allanore Y. High risk of clinical cardiovascular events in rheumatoid arthritis: levels of associations of myocardial infarction and stroke through a systematic review and meta-analysis. Archives of Cardiovascular Diseases. 2010; 103 (4): 253–261.
45. Missala I., Kassner U., Steinhagen-Thiessen E.A Systematic Literature Review of the Association of Lipoprotein(a) and Autoimmune Diseases and Atherosclerosis. International Journal of Rheumatology. 2012; 10: 2012.
46. Aviña-Zubieta J.A, Man A., Yurkovich M., Huang K., Sayre E.C., Choi H.K. Early Cardiovascular Disease After the Diagnosis of Systemic Sclerosis. The American Journal of Medicine. 2016; 129 (3): 324–331.
47. Crowson C.S., Liao K.P., Davis III J.M., Solomon D.H., Matteson E.L., Knutson K.L. et al. Rheumatoid arthritis and cardiovascular disease. American Heart Journal. 2013; 166: 622-628.
48. Rogers R.K., Sakhuja R., Margey R., Stone J.H., Rosenfield K., Jaff M.R. Transient Ischemic Attacks in a 22-Year-Old. The American Journal of Medicine. 2012; 125 (2): 148–154.
49. Hjuler K.F., Böttcher M., Vestergaard Ch., Deleuran M., Raaby L., Bøtker H.E. et al. Increased Prevalence of Coronary Artery Disease in Severe Psoriasis and Severe Atopic Dermatitis. The American Journal of Medicine. 2015; 128 (12): 1325–1334.
50. Shlyankevich J., Mehta N.N., Krueger J.G., Strober В., Johann E.G., Qureshi A.A. et al. Accumulating Evidence for the Association and Shared Pathogenic Mechanisms Between Psoriasis and Cardiovascular-related Comorbidities. The American Journal of Medicine. 2014; 127: 1148–1153.
51. Bećarević M., Singh S., Majkić-Singh N. Lipoprotein (a) and apolipoprotein (a) in primary antiphospholipid syndrome. Clinical Biochemistry. 2007; 40 (5-6): 317–320.
52. Cavagna L., Boffini N., Cagnotto G., Inverardi F., Grosso V. Atherosclerosis and Rheumatoid Arthritis: More Than a Simple Association. Caporali
Mediators of Inflammation. 2012; 8: 2012.
53. Rincón del I., Polak J.F., O’Leary D.H. Systemic inflammation and cardiovascular risk factors predict rapid progression of atherosclerosis in rheumatoid arthritis. Annals of the Rheumatic Diseases. 2015; 74 (6): 1118–1123.
54. Dotsenko N.YA., Gerasimenko L.V., Boyev S.S., Shekhunova I.A., Dedova V.O. Proyavleniya neklassifitsirovannoy displazii soyedinitel'noy tkani v zavisimosti ot vozrasta. Prognoz. Ukrainskiy revmatologicheskiy zhurnal. 2012; 47: 19-23. ( in Russ)
55. Kargapolova M.P., Sorokin A.V. Rasprostranennost' faktorov riska karotidnogo ateroskleroza pri displazii soyedinitel'noy tkani u lits s normal'nym arterial'nym davleniyem i arterial'noy gipertoniyey. Vrach-aspirant. 2012; 50 (1.2): 238-244. ( in Russ)
56. Dedova V.O., Dotsenko N.YA., Boyev S.S., Shekhunova I.A., Gerasimenko L.V. Rasprostranennost' displazii soyedinitel'noy tkani (obzor literatury). Journal of Siberian medical sciences. 2011; 2: 6 ( in Russ).
57. Drokina O.V., Semenkin A.A., Nechayeva G.I., Gyunter S.F., Tumorina N.N. Rol' displazii soyedinitel'noy tkani (nasledstvennykh narusheniy soyedinitel'noy tkani) v izmeneniy elasticheskikh svoystv arteriy. Arkhiv vnutrenney meditsiny. 6: 40-44. 2012. ( in Russ)
58. Ben Salkha M., Repina N.B. Klinicheskaya diagnostika nedifferentsirovannoy displazii soyedinitel'noy tkani. Ros. med.-biol. vestn. 2016; 24 (4): 164-172. ( in Russ)
59. Onufriychuk YU.O., Ragozin O.N., Radysh I.V., Zhuravleva YU.S. Displaziya soyedinitel'noy tkani: rasprostranennost' i spektry fenotipicheskikh proyavleniy v razlichnykh klimaticheskikh poyasakh. Ekologiya cheloveka. 2009; 1: 29-33. ( in Russ)
60. Smetanin M.YU. Displaziya soyedinitel'noy tkani i vnezapnaya serdechnaya smert'. Mezhdunarodnyy zhurnal prikladnykh i fundamental'nykh issledovaniy. 2016; 9-3: 405-408. ( in Russ)

Author
Anna Yu. Afineevskaya
Surgut State Pedagogical University
Postgraduate student
Russion Federation, 628417, Surgut, 50 Let VLKSM st., 10/2
afineevskayaanna@gmail.com

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)