Formation of Haemocoagulative Potential of Blood in the Elderly

Antropova I.P., Yushkov B.G.

Ural Research Institute of Traumatology and Orthopedics named after V.D. Chaklin; Institute of Immunology and Physiology, RAS Ural Branch; Ural Federal University named after the first President of Russia B.N.Yeltsin, Yekaterinburg, Russian Federation

Abstract.
Age features of the haemostatic system were analyzed in patients admitted to the clinic for large joints replacement surgery. It has been shown that with the aging there are increased the activity of internal coagulation pathway and fibrinolysis, the levels of thrombomodulin and von Willebrand factor. At the same time, we observed the decrease in activity of external coagulation pathway, the levels of antithrombin III and plasminogen, platelet count. Multidirectional changes in haemostatic system decrease the stability of coagulative, anticoagulative and fibrinolytic mechanisms in the elderly.

Keywords:
haemostatic system, elderly people

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Authors
Antropova Irina Petrovna
Ural Research Institute of Traumatology and Orthopedics named after V.D. Chaklin
PhD, Senior Researcher
7, Bankovsky alley, 620014, Yekaterinburg, Russian Federation
aip.hemolab@mail.ru

Yushkov Boris Germanovich
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, Ural Federal University named after the first President of Russia B.N.Yeltsin, Yekaterinburg, Russian Federation,
106, Pervomayskaya str., Yekaterinburg, Russian Federation
b.yushkov@iip.urun.ru