FUCOXANTHINE AS A PERSPECTIVE GEROPROTECTOR

DOI: 10.22138/2500-0918-2025-22-3-218-232

K.A. Gavrilova¹, T.A. Vaulina¹, E.A. Vakker¹, E.S. Kolmakova¹,
O.E. Knysh¹, D.S. Erlish¹

¹Ural State Medical University, Yekaterinburg, Russian Federation;

²Institute of Medical Cell Technologies, Yekaterinburg, Russian Federation

Abstract. Introduction. From 2000 to 2019, the average life expectancy increased by 6.5 years worldwide, which led to an increase in the number of diseases characteristic of old age. The search for a geroprotector capable of both increasing life expectancy and improving its quality, preventing the development of age-related diseases, is relevant. The aim of the study was to study the geroprotective properties of fucoxanthin. Materials and methods. A single-center fundamental study was conducted on 60 outbred male ICR/CD1 mice aged 20 months. 60 mice were divided into 2 groups: 1st – 30 mice that did not receive fucoxanthin, 2nd – 30 mice that received orally the drug Fucoxanthin dissolved in water (TargetMol, USA) daily for 8 months. Changes in the general biochemical parameters of blood serum were recorded using the ChemWell 2910 biochemical analyzer from Awarenesstechnology and Spinreact reagents. The total AOA of serum was determined using a Sinnowabs 3000m biochemical analyzer and Vector Best reagents. The reagent “tetramethylbenzidine (TMB) + H₂O₂” for enzyme immunoassay by Diagnostic Systems LLC is used to determine total peroxidase activity. Total AOA of liver homogenate – using the Elabscience kit E-BC-K225-M. The content of malonic dialdehyde (MDA) in liver homogenate was determined using the Elabscience kit E-BC-K025-M. The optical density during the determination of AOA and MDA in the homogenate was recorded on a Multiscan Go ThermoFisher spectrophotometer. Statistical data processing was carried out in Jamovi. The assumption of the normality of the distributions of the indicators is accepted when using the Shapiro-Wilk criterion (W>0.8). Comparison of data obeying the law of normal distribution is the Welch T–test. The survival curve is based on the Kaplan-Meyer method. The Taron-Ware criterion was chosen to calculate the reliability of changes in survival. Results. Our study confirmed the geroprotective properties of fucoxanthin against mammals, showed the antioxidant properties of the drug and the absence of pronounced toxic effects. Conclusions. Fucoxanthin can be considered as a promising geroprotector for clinical use.

Keywords: aging, antioxidant, antioxidant activity, antioxidant protection, fucoxanthin, oxidative stress, geroprotector, life expectancy, markers of aging, lipid peroxidation

There is no conflict of interest.
Contact details of the corresponding author:
Taisija A. Vaulina
taiavaulina@mail.ru
Recieved 02.04.2025
For citation: Maklakova I.Yu., Grebnev D.Yu., Kapralov A.I., Gavrilov I.V., Gavrilova K.A., Vaulina T.A., Vakker E.A., Kolmakova E.S., Knysh O.E., Erlish D.S. Fucoxanthine as a perspective geroprotector. [Online] Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2025, Vol. 22, no. 3, pp. 218–232. DOI: 10.22138/2500-0918-2025-22-3-218-232 (In Russ)

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Authors
Irina Ju. Maklakova
Ural State Medical University
Doctor of Medicine Sciences, Associate Professor, Head of department of normal
physiology
Institute of Medical Cell Technologies
Senior Researcher
makliu@mail.ru
Yekaterinburg, Russian Federation

Dmitrij Ju. Grebnev
Ural State Medical University
Doctor of Medicine Sciences, Associate Professor, Head of department of pathological physiology
Institute of Medical Cell Technologies
Senior Researcher
dr-grebnev77@mail.ru
Yekaterinburg, Russian Federation

Aleksej I. Kapralov
Ural State Medical University
Assistant
alexy_kapralov@mail.ru
Yekaterinburg, Russian Federation

Il'ja V. Gavrilov
Ural State Medical University
Ph.D. biologist. Sciences, Associate Professor
Institute of Medical Cell Technologies
Senior Researcher
iliagavrilov18@yandex.ru
Yekaterinburg, Russian Federation

Ksenija A. Gavrilova
Ural State Medical University
Senior Lecturer
kberlyakova@mail.ru
Yekaterinburg, Russian Federation

Taisija A. Vaulina
Ural State Medical University
Student
taiavaulina@mail.ru
Yekaterinburg, Russian Federation

Ekaterina A. Vakker
Ural State Medical University
Student
katrin-vakker@yandex.ru
Yekaterinburg, Russian Federation

Kolmakova Elizaveta S.
Ural State Medical University
Student
kolmakovaelizaveta15@mail.ru
Yekaterinburg, Russian Federation

Oleg E. Knysh
Ural State Medical University
Student
knysh_oleg4@bk.ru
Yekaterinburg, Russian Federation

Dar'ja S. Jerlish
Ural State Medical University
Student
derlish00@mail.ru
Yekaterinburg, Russian Federation