Functional and Metabolic Activity of Monocytes of Blood at Progressing Tuberculosis of Lungs

Berdyugina O.V., Yershova A.V.

Ural Research Institute of Phthisiopulmonology, Yekaterinburg, Russian Federation

Abstract.
Pathogenesis of progressing of tuberculosis is connected with change of functioning of immune system. The purpose of work is studying of functional and metabolic activity of monocytes of blood at progressing tuberculosis of the lungs, caused drugs steady or drugs sensitive Mycobactérium tuberculósis isolates at men and women. Surveyed 54 patients, from them 29 patients had the diagnosis «infiltrative tuberculosis of lungs», other people were donors of blood. Absorbing and functional and metabolic activity of monocytes estimated a method of a flow cytofluorimetry. Statistical processing of results is carried out with STATISTICA program use. It was established that patients who had Mycobactérium tuberculósis isolates steady against therapy had the reduced quantity of the monocytes capable phagocytosis to a bacterium. Patients who had isolates sensitive to therapy had the increased quantity of the monocytes capable phagocytosis to a bacterium. At all patients with progressing tuberculosis of lungs the metabolic reserve decreased. At men regardless of existence of sensitivity or stability of isolate at progressing tuberculosis the increase in number of monocytes and activation of intracellular mechanisms of bacterial action was noted, at women regardless of existence of sensitivity and stability of isolate at progressing tuberculosis the increased absorbing and reduced bactericidal potential came to light.

Keywords:
tuberculosis of the lungs, progressing form, infiltrative process, pathogenesis

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Authors:
Berdyugina Olga V., berolga73@rambler.ru
Doctor of Biology, leading researcher of laboratory of diagnostic and experimental methods of research

Yershova Anastasia V.
research associate of laboratory of diagnostic and experimental methods of research

Ural Research Institute of Phthisiopulmonology
Russian Federation, 620039, Yekaterinburg, XXII partsjezda st., 50