Characteristic of Cellular Immune Response, Antibody Formation, Quantitative Structure and Phagocytic Activity of Rat’s Peritoneal Cells under Different Gravity Experimental Thyrotoxicosis

Godovalov A.P., Zenkov A.L.

Acad. E.A. Wagner Perm State Medical Academy,
Perm, Russian Federation

Abstract.
Under milder form of thyrotoxicosis it was established stimulation of immune response; the total number of peritoneal leukocytes was increased with predominant increasing in the number of lymphocytes and reduction in the relative number of actively phagocytic cells of the monocyte-macrophage series. Under more severe thyrotoxicosis observed suppressive action of thyroxin on immune response; not revealed changes of the total number of peritoneal cells, but increases their phagocytic activity.

Keywords:
experimental thyrotoxicosis, phagocytic activity, peritoneal phagocytic cells

REFERENCES
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2. Forner M.A., Barriga C., Ortega E. Exercise-induced stimulation of murine macrophage phagocytosis may be mediated by thyroxine. J. Appl. Physiol. — 1996. –Vol. 80(3). – P. 899-903.
3. Shilov Ju.I., Gein S.V., Chereshnev V.A. Influence of blockade of beta-adrenoreceptors and acute stress on antibody formation, delayed type of hypersensitivity, phagocytic cell activity in local immune response. Rus. J. Immunol.- 2001. — Vol. 6(3). — P. 301-308.

Authors
Godovalov Anatoliy Pe., 
AGodovalov@gmail.com
Acad. E.A. Wagner Perm State Medical Academy
PhD, associate professor
85 Ekaterininskaya street, Perm, 614990, Russian Federation

Zenkov Alexander Leonidovich
Student