CHARACTERISTICS OF MORPHOMETRIC PARAMETERS IN TISSUES OF EXUDATIVE LESIONS OF REINKE’S SPACE
M.A. Kovalev¹, E.V. Davydova², L.V. Astakhova³
DOI: 10.22138/2500-0918-2022-19-3-333-338
¹ Branch No. 3 FGBU «3 Central Military Clinical Hospital named after. A.A. Vishnevsky»
of the Ministry of Defense of the Russian Federation, Odintsovo, Russian Federation;
² Chelyabinsk Regional Clinical Hospital, Chelyabinsk, Russian Federation;
³ Multidisciplinary Center for Laser Medicine, Chelyabinsk, Russian Federation
Abstract. Reinke’s edema, polyps and nodules of the vocal folds, belong to the exudative lesions of the Reinke’s space (EPPR), have common features of pathogenesis, are similar in etiology, morphogenesis and clinical manifestations, but have a characteristic topography of the location on the vocal folds. Cellular elements of both the lamina propria, the subepithelial zone, and the connective tissue take part in maintaining tissue and immune homeostasis. The study of the morphometric features of EPPR in representatives of vocal professions was the aim of the work. Microscopic studies in 47 tissue samples were performed on a DMRXA microscope (Leika, Germany) using the Image Scope M program (Germany). Statistical processing of the material was carried out using the Statistica 10.0 for Windows software package. Our data showed a number of features of the cellular composition and stromal component in various EPPRs. The tissues of angiomatous polyps and vocal nodules contained a large number of fibroblasts and had a high specific area of the vasculature. In tissue samples of myxoid polyps and with Reinke’s edema, a significant increase in the number of lymphocytes, histiocytes, the height of the epithelial layer and the specific area of the fluid component of the connective tissue was shown. The absence of an inflammatory process was indicated by the minimum content of all ESPR of neutrophils and macrophages in the tissues.
Keywords: exudative lesions of Reinke’s space, morphometry
There is no conflict of interest.
Contact details of the corresponding author:
Evgeniya V. Davydova
davidova-ev.med@yandex.ru
Received 28.07.2022
For citation:
Kovalev M.A., Davydova E.V., Astakhova L.V. Haracteristics of morphometric parameters in tissues of exudative lesions of Reinke’s space. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2022, Vol. 19, no. 3, pp. 333–338. DOI: 10.22138/2500-0918-2022-19-3-333-338 (In Russ)
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Authors
Mikhail A. Kovalev
Branch No. 3, Federal State Budgetary Institution “3, Central Military Clinical Hospital named after V.I. A.A. Vishnevsky» of the Ministry of Defense of the Russian Federation
Head of the Department of Otorhinolaryngology
1 Marshal Biryuzova st. Moscow region Odintsovo Russian Federation 143000
lor.kovalev@mail.ru
Evgeniya V. Davydova
Chelyabinsk Regional Clinical Hospital, Russia
MD, Head of the Rehabilitation Department
70 Vorovskogo st. Chelyabinsk Russian Federation 454048
davidova-ev.med@yandex.ru
Lyudmila V. Astakhova
GBUZ Multidisciplinary Center for Laser Medicine
Candidate of Medical Sciences, Head of the Department of Exploratory Research
287 Pobedy av. Chelyabinsk, Russian Federation, 454138