Immunophysiological Parallels in Women with Physiological Pregnancy and in Vitro Fertilization
УДК: 612.017
DOI: 10.22138/2500-0918-2019-16-4-402-409
Yu.S. Chekhova, E.A. Kashuba, S.V. Solov'yova, M.V. Antonova
Tyumen State Medical University, Tyumen, Russian Federation
Abstract. Evaluation of individual indicators of the system cannot fully reflect its functional state. In this regard, it is advisable to apply system characteristics, such as the connectedness of components and their dynamics. Aim: to identify immunophysiological correlates in patients with a physiologically induced pregnancy and in vitro fertilization. Materials and methods. Object of study: clinically healthy women before pregnancy and in the first trimester (I group), patients with tubal-peritoneal infertility at the planning stage and after an effective in vitro fertilization (IVF) procedure (II group), women with an unsuccessful IVF attempt (III Group). Correlation matrices for physiological indices and immunological parameters were calculated. The correlation coefficients for each pair of features were compared. The integral characteristics of correlation matrices were studied. Results. Patients with a physiologically induced pregnancy were distinguished by a calm state of the system in the pregravid period and moderate activation after conception. Group II patients also had no signs of system activation at the stage of preparation for IVF. However, the dynamics of the indicators revealed a more pronounced tension after pregnancy. Group III recorded a significant increase in the connectedness of components in the system before the IVF procedure and an increase in indicators after the end of the program, which could be one of the factors of an unfavorable outcome. Significant relationships between physiological and immunological parameters reflected the dynamics and nature of changes depending on the period of examination and the method of pregnancy, as well as on the result of IVF. The predominance of the number of correlation bonds and a change in their polarity in patients with an ineffective IVF program indicated a pronounced immunological imbalance against the background of a failure of adaptation and pronounced parasympathetic influences.
Keywords: pregnancy, infertility, in vitro fertilization, immunological status, physiological indices, correlations
Received 25.11.2019
For citation: Chekhova Yu.S., Kashuba E.A., Solov'yova S.V., Antonova M.V. Immunophysiological Parallels in Women with Physiological Pregnancy and In Vitro Fertilization. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2019, Vol. 16, no. 4, pp. 402–409. DOI: 10.22138/2500-0918-2019-16-4-402-409 (In Russ)
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Authors
Julia S. Chehova
Teaching Assistant
infect-tgma@mail.ru
ORCID iD 0000-0002-0982-000
Eduard A. Kashuba
Doctor of Medical Sciences. Professor
infect-tgma@mail.ru
ORCID iD 0000-0001-9832-7623
Svetlana V. Solov'eva
Doctor of Medical Sciences. Professor
svsolov@mail.ru
ORCID iD 0000-0001-8481-7664
Mariya V. Antonova
Teaching Assistant
antonovamariav@mail.ru
ORCID iD 0000-0001-7859-1101
Tyumen State Medical University
54 a Odesskaya Str. Tyumen 625023 Russian Federation