SII INDEX IN THE ASSESSMENT OF SYSTEMIC INFLAMMATORY RESPONSE IN PATIENTS WITH HYPERGLYCEMIA
DOI: 10.22138/2500-0918-2024-21-4-367-376
Y.A. Zhuravleva¹, Y.V. Turyanskaya²,³, K.V. Zapasnaya⁴, L.R. Serazetdinova⁴
¹Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, Yekaterinburg, Russian Federation;
²FSBEI HE «Urals State Medical University» of the Ministry of Healthcare of the Russian Federation, Yekaterinburg, Russian Federation;
³SAHI SR Regional Specialized Center for Medical Rehabilitation «Lake Chusovskoye», Yekaterinburg, Russian Federation;
⁴FSAEI HE «Ural Federal University named after the First President of Russia B.N.Yeltsin», Yekaterinburg, Russian Federation
Absrtract. The paper presents the analysis of SII index (systemic immune-inflammation index) in patients with hyperglycemia with different degrees of decompensation (type 2 diabetes mellitus – T2DM, prediabetes). The aim of the study: to analyze the possibility of assessing the severity of inflammatory changes in patients with hyperglycemia and its prognostic role in the development of T2DM. Materials and methods. The retrospective study included patients with hyperglycemia, including 26 patients with T2DM, 10 patients with prediabetes. The control group consisted of healthy volunteers (n=22). Fasting and postprandial glucose and C-peptide levels, glycated hemoglobin (HbA1c), erythrocyte sedimentation rate (ESR), leukogram parameters and platelet count were determined in all patients, SII index was calculated. The results of the study showed that according to the majority of leukogram parameters and integral SII index, inflammatory changes were more pronounced in T2DM. However, the diagnostic efficiency of the SII index was low. Comparative analysis of the SII index in the groups of patients with hyperglycemia and in the control group showed its comparability, which also casts doubt on the possibility of assessing the inflammatory status of patients using this index.
Keywords: SII index, hyperglycemia, diabetes mellitus, prediabetes
There is no conflict of interest.
Contact details of the corresponding author:
Yulia A. Zhuravleva
jazhur@mail.ru
Received: 01.09.2024
For citation: Zhuravleva Y.A., Turyanskaya Y.V., Zapasnaya K.V., Serazetdinova L.R. SII index in the assessment of systemic inflammatory response in patients with hyperglycemia. [Online] Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2024, Vol. 21, no. 4, pp. 367–376. DOI: 10.22138/2500-0918-2024-21-4-367-376 (In Russ)
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Auhtors
Yulia A. Zhuravleva
Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences (IIP UB RAS)
PhD, senior researcher (Laboratory for Inflammation Immunology)
Yekaterinburg, Russian Federation
jazhur@mail.ru
Yulia V. Turyanskaya
Federal State Budgetary Educational Institution of Higher Education «Urals State Medical University» of the Ministry of Healthcare of the Russian Federation (FSBEI HE USMU MON Russia)
PhD, Assistant of the Department of Hospital Therapy
Yekaterinburg, Russian Federation
tiger2003r@mail.ru
Ksenia V. Zapasnaya
Federal State Autonomous Educational Institution of Higher Education «Ural Federal University named after the First President of Russia B.N.Yeltsin» (Ural Federal University named after the first President of Russia B.N.Yeltsin)
Student of the Institute of Natural Sciences and Mathematics
Yekaterinburg, Russian Federation
ksyu.pretty02@mail.ru
Lilia R. Serazetdinova
Federal State Autonomous Educational Institution of Higher Education «Ural Federal University named after the First President of Russia B.N.Yeltsin» (Ural Federal University named after the first President of Russia B.N.Yeltsin)
Student of the Institute of Natural Sciences and Mathematics
Yekaterinburg, Russian Federation
serazetdinoval11@gmail.com