CHANGE OF ESTROGEN RECEPTOR EXPRESSION IN BREAST CANCER CELLS IN LOCOREGIONAL METASTASES

Konyshev K. V., Brilliant A. A., Sazonov S. V.

GAUZ SO Institute of Medical Cell Technologies, Ekaterinburg, Russian Federation;
GBOU VPO Ural State Medical University of Ministry of Health of Russia, Ekaterinburg, Russian Federation

Absrtact.

Breast cancer is the leading oncologic disease in women in the world. Hormonal therapy is recommended, while operation material or biopsy specimen of tumor has positive immunohistochemical reaction with antibodies to steroid hormone receptors. Some discordance of hormone receptor rate between metastases and primary tumor exists. This can lead to failure of hormone therapy. This investigation aims to find and characterize the discordance between the primary tumor and metastases. In this study operation material by 91 patients was investigated. All cases were divided in three groups — with negative ER-status of primary lesion (32 cases), with Allred rate 2–6 (37 cases) and with 7–8 Allred rate (22 cases). In each group expression of ER of primary and metastatic tumors was compared, using Wilcoxon test. Only second group had significant difference in ER expression levels (p < 0,01). In this group the shift of rate in metastases was observed in all cases, and in 31 cases it was elevated. Findings complement the data about HR rate discordance of primary tumor and metastases.

Key words:

breast cancer, estrogen receptors, metastases, discordant receptor status

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Authors
Konyshev Konstantin V.
GAUZ SO Institute of Medical Cell Technologies
Pathologist
Russian Federation, 620137, Ekaterinburg, Vilonova, 76 a
GBOU VPO Ural State Medical University of Ministry of Health of Russia
PhD student of department of Histology, cytology and embryology
kon-konyshev@yandex.ru

Brilliant Aleksandr A.
GAUZ SO Institute of Medical Cell Technologies
PhD, Senior researcher
imct@celltechnologies.ru

Sazonov Sergey V.
PhD, MD, Professor
GAUZ SO Institute of Medical Cell Technologies
Head of Laboratory of Pathomorphology
GBOU VPO Ural State Medical University of Ministry of Health of Russia
Head of department of Histology, cytology and embryology
imct@celltechnologies.ru