Changes in the Indices of Immunity and the Order Parameter, Reflecting the Relative Degree of Randomness of the System (e) After Exposure to the Cold on the Human Body
DOI: 10.22138/2500-0918-2018-15-2-271-277
A.I. Levanyuk
Institute of Environmental Physiology of Federal Center for Integrated Arctic Research Russian Academy of Sciences, Arkhangelsk, Russian Federation
Abstract. Immunological reactivity is an energy-consuming process and requires constant replenishment of energy resources. Voltage immune background causes the reduction of reserve capacity, timely immune response. It is known that local and General cooling affects the decrease in the content of peripheral blood T-lymphocytes, B-cells, antibody formation in practically healthy people. The aim of the investigation was to find out the changes in the parameters of immunity and the order parameter reflecting the relative degree of chaoticity of the system (E) after exposure to cold on the body. Materials and methods of research. The comprehensive study included 35 healthy volunteers before and after short total cooling (for 5 minutes in a cold chamber at –25°C) was determined in a wide range of immunological parameters, and carried out registration of crowngrams of the fingers on a hardware-software complex «Chronostop». Lymphocyte subpopulations were determined by indirect immunoperoxidase reaction using monoclonal antibodies produced by NPC «Medbiospektr» (Moscow). The contents of cytokines, CEA was determined by «competitive» enzyme immunoassay reagents «BIOSOURSE». Phagocytic activity of neutrophils was determined using a test set of chemical company «Realplex» (Chita). Results. The study showed that after a short-term General cooling of a person at –25°C for 5 minutes, 22.86% of the surveyed persons registered an increase in the entropy parameter, indicating signs of a decrease in the stability of the elements of the system, which is associated with a higher background of proinflammatory cytokines (IL-6 and TNF-?). The decrease in the stability of the elements of the system is manifested by less pronounced migration reactions of blood cells, mainly lymphocytes, to the cold factor. Low level of response vessels and migration of cells may not provide a robust and integrated restructuring of the vasoconstrictor response.
Keywords: cold, entropy, lymphocytes, cytokines
Received 09.04.2018
For citation:
Levanyuk A.I. Changes in the Indices of Immunity and the Order Parameter, Reflecting the Relative Degree of Randomness of the System (E) after Exposure to the Cold on the Human Body. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2018, Vol. 15, no. 2, pp. 271–277. DOI: 10.22138/2500-0918-2018-15-2-271-277 (In Russ)
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Author
Anna I. Levanyuk
Institute of Environmental Physiology of Federal Center for Integrated Arctic Research Russian Academy of Sciences Russian Federation
Cand. Sci. (Biology), Senior Researcher, Laboratory of Ecological Immunology
Russian Federation, 163061, Arkhangelsk, Lomonosov Ave., 249
vita0111@inbox.ru
