Changes of Interleukins Level in the Early Posttraumatic Period in Victims with Thoracoabdominal Injuries
DOI: 10.22138/2500-0918-2017-14-4-375-380
E.P. Sorokin, Ye. G. Butolin, Ye. V. Shilyaeva, V.G. Ivanov
Izhevsk State Medical Academy, Izhevsk, Russian Federation
Abstract. Introduction. One of the manifestations of the response to injury is systemic inflammatory response syndrome associated with an imbalance of anti- and proinflammatory cytokines. Changes in the concentration of interleukins correlated with the incidence of posttraumatic complications and mortality. The goal of the study is identification of changes in the content of interleukins in the early posttraumatic period in patients with thoracoabdominal injuries. Materials and methods. The concentration of interleukin-1ß and interleukin-10 in venous blood by ELISA determined in 24 male victims with thoracoabdominal injuries in the first day of treatment in a hospital. Results. The highest levels IL-1ß and IL-10 were determined during surgery, the minimal value after 6–12 hours after surgery. The content of IL-1ß was higher in patients under the age of 40 years. The victims in the older age groups the trend was the opposite. The level of IL-10 decreased during the day in both age groups. Significant changes in the concentrations of IL-1ß in patients with signs of alcoholic intoxication have been identified. In the absence of the maximum value of the substance noted during surgery and for hours afterwards. Significant differences in the content of IL-10 depending on the signs of alcohol intoxication is not revealed. The concentration of IL-1ß and IL-10 during the surgery were higher in cases when infectious complications developed. Conclusion. The most pronounced increase in the content of IL-1ß and IL-10 during surgical intervention with a subsequent decrease during the first days of inpatient treatment observed in victims younger than 40 years, in the absence of signs of intoxication at the time of admission and in the development of infectious complications of traumatic disease.
Keywords: thoracoabdominal injury, interleukin-1ß, interleukin-10
Received 07.09.2017
For citation:
Sorokin E.P., Butolin Ye.G., Shilyaeva Ye.V., Ivanov V.G. Changes of interleukins level in the early posttraumatic period in victims with thoracoabdominal injuries. Vestn. Ural. Med. Akad. Nauki. Journal of Ural Medical Academic Science. 2017, Vol. 14, no. 4, pp. 375–380. DOI: 10.22138/2500-0918-2017-14-4-375-380 (In Russ)
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Authors
Eduard P. Sorokin
Cand. Sci. (Med.), Associate Professor of Chair of Surgical Diseases with course of Anesthesiology and Resuscitation
ep.sorokin@yandex.ru
Yevgenij G.Butolin
Doc.Sci.(Med.), Professor, Head of Chair of Clinical Biochemistry and Laboratory Diagnosis
butoline@mail.ru
Yelena V. Shilyaeva
Assistant of Chair of Surgical Diseases with course of Anesthesiology and Resuscitation
shil-elena@yandex.ru
Vadim G.Ivanov
Cand. Sci. (Med.), Associate Professor of chair of Clinical Biochemistry and Laboratory Diagnosis
butoline@mail.ru
Izhevsk State Medical Academy
426063, Russian Federation, Udmurt Republic, Izhevsk, Promyshlennaya street, 52