The comparative characteristic of megakaryocytic’s and mast cell’s reaction on ionizing radiation influence

Zerchaninova E.I., Butorina E.V., Khlynova R.I.

Abstract.

Nowadays megakaryocytic research at extreme factors organism influence isn’t studied well enough. There is very little data about megakaryocytic and thrombocytic regulation. Scientists connect the blood thrombocyte quantity reduction at rat radiation with spinal cells proliferation infringement and with inner vessel thrombocyte aggregation. Experiment has shown, that megakaryocyte restoration after sublethal radiations occurs due to more mature survived cells. Huge role in haematopoiesis is given to mast cells that actively participate in local blood making regulation, due to biologically active substances allocation. Radiation leads to degranulation and biologically active substances emission in the environment. The purpose of our work is to reveal the different doze of radiation influence on megakaryocytic process and mast cells. During the experiment has been established that:
1. Irradiation influence is suppression of proliferation and cells differentiations processes of both megakaryocytic and mast cells, more proof in the latter case.
2. The irradiation causes the decrease of megakaryocytic functional activity .
3. The irradiation causes the increase of degranulation mast cells factor.

Keywords:

mast cells; thrombocyte; megakaryocyte; irradiation; bone marrow

Authors
Zerchaninova Elena I.
GBOU HPE Ural State Medical Academy of Health Ministry of Russia, Ekaterinburg
Russia, 620028, Ekaterinburg, Repina st., 3
e-mail: zerchaninova@mail.ru

Butorina Elena V.
Institute of immunology and physiology Ural department of Russian Academy of Sciences, Ekaterinburg
Russia, 620049, Ekaterinburg, Pervomaiskaya st., 106.
e-mail: butorinaev@um.zra.ru

Khlynova Regina I.
GBOU HPE Ural State Medical Academy of Health Ministry of Russia, Ekaterinburg
Russia, 620028, Ekaterinburg, Repina st., 3.
e-mail: khlynova-r.i@yandex.ru