Killer Activity of Immunocompetent Cells in the Arctic Residents

Sergeeva T.B., Shchegoleva L.S.

The Institute of Environmental Physiology of Ural Branch of Russian Academy of Science, Arkhangelsk, Russian Federation

Abstract. Health of the population in the North, as the alien and the native, is under constant exposure to extreme climatic factors, which leads to the formation of a specific “northern type” body functioning and northern pathology.
Functional reactivity of the immune system is influenced by various environmental factors, therefore monitoring of the immune status over time remains relevant. However, it should be noted that the current time period are virtually no data characterizing the immune status of indigenous (scanty) of the Far North.
In the period from December 2009 to December to 2011 in Nes Nenets Autonomous District were held 2 expedition. It was immunological examinations of 42 people residing in Nes NAO: 20 women and 22 men aged 19 to 50 years. The content phenotypes lymphocytes (CD3+, CD4+, CD8+, CD16+, CD95+) in peripheral blood was determined by indirect immunoperoxidase reaction with monoclonal antibodies (SPC “MedBioSpektr”, Moscow) on lymphocyte preparations “dried drop.”
Locals Arctic revealed transcendent content suppressor killer (CD8+) in 45%, and natural killer cells (CD16+) in 40% of surveyed individuals with background widespread among the population deficit mature functionally active T cells (CD3+) in 95% of cases, the T-helper failure in 46% and have a very low concentration of cells (CD95+) in 53% of the surveyed individuals.

Keyworlds: Polar Region, immune status, killer activity

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Authors
Sergeeva Tatyana B. Tanya — 86@mail.ru
The Institute of Environmental Physiology of Ural Branch of Russian Academy of Science, Arkhangelsk, Russia, Postgraduate
Shchegoleva Lubov S. shchegoleva60@mail
The Institute of Environmental Physiology of Ural Branch of Russian Academy of Science, Arkhangelsk, Russia
Doktor biologicheskih nauk, professor, director The Institute of Environmental Physiology of Ural Branch of Russian Academy of Science
Russian Federation 163000, Arkhangelsk, Lomonosova 249