Clinical Significance of Microscopic Metastases in Axillary Lymph Nodes in Primary Operable Breast Cancer. (Literature Review)
DOI: 10.22138/2500-0918-2018-15-1-116-123
V.E. Ponomarev, J.V. Vishnevskaja, N.I. Mehtieva, S.B. Polikarpova, E.A. Bogush, L.N. Ljubchenko
I.M. Sechenov FirstMoscow State Medical University, Moscow, Russian Federation;
N.N. Blokhin National Medical Research Center of Oncology, Moscow, Russian Federation
Abstract. Relevance. Axillary nodal status is an important prognostic factor in guiding locoregional and systemic treatment for breast cancer. Sentinel lymph node biopsy has changed axillary staging by replacing axillary lymph node dissection in node-negative women. Objectives. Our objectives were to study the significance of micrometastases and isolated tumor cells in axillary lymph nodes for the prognosis and survival time of breast cancer patients. Conclusions and perspectives. Even in select patients whose sentinel lymph nodes contain metastases, Sentinel lymph node biopsy alone has become an accepted method of managing the axilla. Identification of micrometastases through immunohistochemical analysis of sentinel lymph nodes that are tumor free on hematoxylin and eosin staining does not confer additional clinical benefit.
Keywords: Sentinel lymph node, Isolated tumor cells, Micrometastasis, Macrometastasis
Received 22.01.2018
For citation:
V.E. Ponomarev, J.V. Vishnevskaja, N.I. Mehtieva, S.B. Polikarpova, E.A. Bogush, L.N. Ljubchenko. Clinical Significance of Microscopic Metastases in Axillary Lymph Nodes in Primary Operable Breast Cancer. (Literature Review). Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2018, Vol. 15, no. 1, pp. 116–123. DOI: 10.22138/2500-0918-2018-15-1-116-123 (In Russ)
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Authors
Valery E. Ponomarev
I.M. Sechenov FirstMoscow State Medical University
Postgraduate student
8, Trubetskaya St., 119991 Moscow, Russian Federation
valeryponomarev321@gmail.com
Yana V. Vishnevskaya
N.N. Blokhin National Medical Research Center of Oncology
Cand. Sci. (Med.), Senior Researcher, Pathologist Department of Pathological Anatomy of Human Tumors
23, Kashirskoye sh., 115478 Moscow, Russian Federation
yana_vishn@list.ru
Nigar I. Mehtieva
N.N. Blokhin National Medical Research Center of Oncology
Cand. Sci. (Med.), Doctoral student of the Department of Reconstructive and Vascular Surgery
23, Kashirskoye sh., 115478 Moscow, Russian Federation
ladymed77@hotmail.com
Svetlana B. Polikarpova
I.M. Sechenov FirstMoscow State Medical University
Dr. Sci. (Med.), Professor
8, Trubetskaya St., 119991 Moscow, Russian Federation
svetaonc@mail.ru
Elena A. Bogush
N.N. Blokhin National Medical Research Center of Oncology
Cand. Sci. (Med.), Senior Researcher, Department of Diagnosis of Tumors
23, Kashirskoye sh., 115478 Moscow, Russian Federation
Elena_bogush@yahoo.com
Lyudmila N. Lyubchenko
I.M. Sechenov FirstMoscow State Medical University
Dr. Sci. (Med.), assistant professor
8, Trubetskaya St., 119991 Moscow, Russian Federation
clingen@mail.ru