Clinical and ultramorfologic determinants of the miometrium during powerless labour
Milyaeva N.M., Kovalev V.V., Tulakina L.G., Pichugova S.V.,
Kleyn A.V., Beykin Y.B.
Abstract. An in-depth study of the morphology and identification of ultra morphostructural determinants myometrium in complicated childbirth uterine inertia is relevant to the ability to forecast and adequate therapy.
Objective: To investigate the ultrastructural characteristics of mitochondrial pathology myometrium at the powerless labor, using high-quality electron microscopic analysis of material and methods.
Material and methods. The study included 10 pregnant women: I group — five women whose labors proceeded with the powerless labor, group II — 5 women — with a coordinated labor. By electron microscopic examination watched over 200 sections. Presented to the demonstration 27 electron microscopic image.
The results of the study. During the electron microscopic examination of samples of the myometrium camping identified criteries for the existence of mitochondrial disease, which give grounds to speak about the significance of the weakness of their labor. With the weakness of labor activity occurs ultramikrostrukture myometrium change with the formation of degradation of cell architecture, including severe destruction of the cell nucleus. Those most exposed to the defeat of the mitochondria in muscle cells, endothelial cells of blood vessels, which leads to malnutrition of the myometrium. Describe the pathologic changes in the myometrium at the weakness of labor make appropriate limitation of induction of labor. Further systematic study of vital signs of pregnancy may contribute to the classification of the weakness of labor as a mitochondrial disease.
Keywords: powerless labor, mitochondrial pathology, myometrium, electron microscopic examination
REFERENCES
1. Podtetenev AD Bratchikova TV, Koktaysh GA Regulation of labor. M .: People's Friendship University, 2004.53
2. Zefirova ETC. Clinical and pathogenetic significance of chronic urogenital infection in the development of uterine abnormalities in women: Author. Dis. … Doctor. honey. Sciences. Kazan, 2007. 45 p.
3. Algovik M., Nilson E., Cnattingius S., Lichtenstein P. Genetic influence on dystocia. Acta. Obstet. Ginecol. Scand. 2004; 83: 9: 832-837.
4. Kritskaya IA Features of early neonatal period in newborns from mothers with the weakness of labor: Author. Dis. … Cand. honey. Sciences. Moscow, 2005.
5. Zabozlaev FG, Milovanov AP, Barkhin TG Pathology of the uterus at the weakness of labor. Archives of Pathology. 2006; 5: 30-34.
6. VV Abramchenko The concept of energy deficit and impaired mitochondrial function. Journal of Obstetrics and gynecological diseases. 2001; 4: 46-52.
7. Malyutina EA, Pavlova TV, Petruhin VA Methods of scanning microscopy in the study of the structure of the uterus and placenta. Scientific statements BSU. Series: Medicine. Pharmacy. 2011. Volume 16, 22-1.
8. Chereshnev VA Pichugov SV Tulakina LG, Klein AV Savinov TL, Beykin Ya The ultrastructure of sperm in normal and patologii.- Yekaterinburg: RIO UB RAS. 2013 -84.
9. Kuz'minykh TW modern medical methods of preparation for childbirth in complicated pregnancy (clinical and experimental study). Author. Dis. Doctor. honey. Sciences. St. Petersburg, 2008. -45 p.
10. Monir-Bishty E., Pierce SJ, Kupittayanant S., Shmygol A. The effects of metabolic inhibition on intracellular calcium and contractility of human myometrium. B.J.OG. 2003; 110: 12: 1050-1056.
11. Sanchez-Ramos L., Quillen M.J., Kaunitz A.M. Randomized trial of oxytocin alone and with propranolol in the management of dysfunctional labor. Obstet. Gynecol. 1996; 88: 4: 517-520.
Authors
Milyaeva Natalia M.
MD, assistant professor of obstetrics and gynecology FPC and PCB, Head OAPB maternity hospital №14 UIA GKB
soneta64@rambler.ru
Kovalev Vladislav V.
MD, Professor, Head of the Department of Obstetrics and Gynecology, FPC and PCB
vvkovalev55@gmail.ru
Ural State Medical University
Russian Federation, 620028, Yekaterinburg, ul. Repin, 3
Tulakina Lyudmila G.
MD, Head of the Laboratory of Electron Microscopy
ekb-lem@mail.ru
Pichugovа Svetlana V.
MD, a physician Laboratory of Electron Microscopy
ekb-lem@mail.ru
Klein Alex V.
MD, a physician Laboratory of Electron Microscopy
ekb-lem@mail.ru
Beykin Yakov B.
MD, professor, honored doctor of the Russian Federation, member of the Russian Academy of Sciences, chief physician UIA «Clinical and Diagnostic Center»
ekb-lem@mail.ru
MAU «Clinical and Diagnostic Center», Yekaterinburg
Russian Federation, 620144, Yekaterinburg, ul. March 8, d.78 V
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)