SYSTEM INFLAMMATORY RESPONSE SYNDROME PATHOGENESIS COMPONENTS IN ACUTE PERITONITIS
DOI: 10.22138/2500-0918-2020-17-1-26-32
A.P. Vlasov, O.V. Markin, V.V. Shhapov, O.V. Revva, N.S. Shejranov, F.F. Ali, I.S. Tomilin
National Research Ogarev Mordovia State University, Saransk, Russian Federation
Abstract. Aim. To study lipid peroxidation, phospholipase activity, anaerobic glycolysis phenomena, and the state of the hemostasis system in the tissue structures of the intestinal and peritoneal organs, and target organs of the liver, kidneys, lungs, heart at the model of acute peritonitis. Material and methods. Experiments on outbred adult dogs (n=21), which under anesthesia simulated acute fecal peritonitis with subsequent (one day later) laparotomy, sanitation of the abdominal cavity. In the control stages of the observation period (1, 2, 3, 5 days), blood was taken, relaparotomy, tissue biopsy of the organs examined. In the tissues of the organs diene conjugates, malonic dialdehyde, phospholipase A2 activity, superoxide dismutase activity, lactic acid content, pyruvic acid content were determined, the study of the state of the blood hemostasis system, the evaluation of the fugctonal activity of the investigated organs. Results. In acute peritonitis, a increase in the products of lipid peroxidation, an increase in the activity of phospholipase A2, a decrease in the activity of superoxide dismutase were recorded not only in the tissues of the intestine and peritoneum, but also in the tissues of the liver, kidneys, lungs, heart,. These changes were accompanied by a significant increase in the products of anaerobic glycolysis in tissues. Abnormalities in the hemostasis system were established in the form of hypercoagulemia, which was significantly aggravated (relative to normal) with the addition of tissue extracts of the organs, which indicated a modification of the tissue factor and, probably, its hyperexpression. Identified pathological changes in organs and tissues correlated with the severity of signs of their dysfunction. Conclusion In the development of the systemic inflammatory response syndrome at the initial stages oxidative phenomena, activation of phospholipase A2, disturbances of the blood coagulation system at the organism level, which are trigger for the cascade of pathophysiological phenomena in various target organs (liver, kidneys, lungs, hearts), leading to the development of multiple organ failure.
Keywords: systemic inflammatory response, peritonitis, oxidative stress
There is no conflict of interest.
Contact details of the corresponding author:
Aleksey P. Vlasov
vap.61@yandex.ru
Received 10.12.2020
For citation:
Vlasov A.P., Markin O.V., Shhapov V.V., Revva O.V., Shejranov N.S., Ali F.F., Tomilin I.S. System inflammatory response syndrome pathogenesis components in acute peritonitis. Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2020, Vol. 17, no. 1, pp. 26–32. DOI: 10.22138/2500-0918-2020-17-1-26-32 (In Russ)
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Authors
Aleksey P. Vlasov
Dr. Sci. (Med.), Professor, Head of the Department of Faculty Surgery
Oleg V. Markin
Cand. Sci. (Med.), associate professor of the department of faculty surgery
Vyacheslav V. Shchapov
Assistant of the Department of Faculty Surgery
Oksana V. Revva
Applicant for the department of faculty surgery
Nikita S. Sheyranov
Cand. Sci. (Med.), Assistant of the Department of Faculty Surgery
Fuad Farid Ali
Postgraduate Student, Department of Faculty Surgery
Ilya S. Tomilin
5 year student of the Medical Institute
National Research Ogarev Mordovia State University
68 Bolshevitskaya str. Saransk Russian Federation 430005
vap.61@yandex.ru