The study of effectiveness and the safety of the use of a new composition based on cellular products in the treatment of periodontitis (in experimental animals)
DOI: 10.22138/2500-0918-2018-15-4-607-611
E.N. Svetlakova, J.V. Mandra, I.V. Svezhukhin, D.A. Sichkar,O.G. Makeev, L.G. Polushina, V.V. Bazarny
Ural State Medical University, Yekaterinburg, Russian Federation
Abstract. The aim of the study was to study the wound healing properties of compositions based on cellular products in an animal experiment. Materials and methods: In the Department of Molecular and Cellular Technologies of the Central Research Institute of USMU, a new personalized composition based on cellular products was proposed. A study of the acute toxicity of the composition was carried out on 10 white mice, the local irritant effect on rabbits was determined, and the efficacy of the drug was studied in 92 rats. A morphological study and a set of laboratory tests were carried out. The results of the experimental study of the new composition indicate the absence of negative reactions. Conclusion: The results of the experimental study of a new composition containing cellular products indicate that there is no acute toxicity of the components. The test composition does not have a local irritant effect. The change in nonspecific inflammatory indices in the blood of laboratory animals after application of the studied composition was established: the number of white blood cells at the end of treatment is 29% lower than in the control group, ALT — by 68%.
Keywords: periodontitis, composition based on cellular products, laboratory animals
Received 14.05.2018
For citation:
Svetlakova E.N., Mandra J.V., Svezhukhin I.V., Sichkar D.A., Makeev O.G., Polushina L.G., Bazarny V.V. The study of effectiveness and the safety of the use of a new composition based on cellular products in the treatment of periodontitis (in experimental animals). Vestn. Ural. Med. Akad. Nauki. = Journal of Ural Medical Academic Science. 2018, Vol. 15, no. 4, pp. 607–611. DOI: 10.22138/2500-0918-2018-15-4-607-611 (In Russ)
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Authors
Elena N. Svetlakova
Cand. Sci. (Med.), Assistant, Department of propaedeutics and physiotherapy of dental diseases
svet_anel11@mail.ru
Yulia V. Mandra
Dr. Sci. (Med.), Professor, Vice-rector for science and innovation, Head of the Department of Preclinical dentistry and Physiotherapy of dental desiases
jmandra@mail.ru
Ilya V. Svezhukhin
Student
ilyasvezhukhin@gmail.com
Darya A. Sichkar
Senior Laboratory Assistant of the Department of Biology
sichkar2017@yandex.ru
Oleg G. Makeev
Dr. Sci. (Med.), Professor, Head of the Department of Molecular and Cell Technologies
larim@mail.ru
Larisa G. Polushina
Scientific employee, Department of general pathology of the Central Research Laboratory polushina-larisa@bk.ru
Vladimir V. Bazarny
Dr. Sci. (Med.), Professor of the Department of Clinical Laboratory Diagnostics and Bacteriology
vlad-bazarny@yandex.ru
Ural State Medical University
620028, Russian Federation, Yekaterinburg, Repin street, 3
