Mechanisms of positive and negative modulation of the efficiency of the activation of adrenoceptors and other receptors associated with g-protein (Review). Communication 2. Endogenous sensitizer of beta-adrenergic receptors (Esbar) as a positive modulator
DOI: 10.22138/2500-0918-2016-15-3-112-136
V.I. Tsirkin, A.D. Nozdrachyov, R.Yu. Anisimov, E.N. Sizova,
T.V. Polezhaeva,S.V. Khlybova, M.A. Morozova,
A.N. Trukhin, Yu.V. Korotaeva, A.A. Kunshin
Kazan State Medical University, Kazan, Russian Federation;
Vyatka State University; Kirov, Russian Federation;
Saint Petersburg State University; St. Petersburg, Russian Federation;
Ural State Medical University; Yekaterinburg, Russian Federation;
Vyatka Social and Economic Institute; Kirov, Russian Federation;
Institute of Physiology Komi Scienсe Centre, Syktyvkar, Russian Federation;
Kirov State Medical Academy; Kirov. Russian Federation
Abstract. The evidences of the presence in the serum of blood and other fluids of the human body (cerebrospinal fluid, amniotic fluid, urine, saliva) positive modulator of beta-AR direct action — endogenous sensitizer of beta-adrenergic receptors (ESBAR) presented in the communication 2. It is a water-soluble substance with low molecular weight. His peers are histidine, tryptophan, tyrosine, and mildronat and preduktal. Separate dilutions of human and animal serum (as a source ESBAR) and its analogs can rapidly (within 1–3 minutes) and reversibly increase the effectiveness of activation of beta- adrenoceptors (beta-AR) of smooth muscles of rat uterus, bovine coronary artery, bovine renal artery, cow trachea, rat stomach and myocardium of frog, rat, and human, and human erythrocytes and platelets particularly if initially effectiveness of activation of beta-AR was reduced under the influence of ozone, or lysophosphatidylcholine or beta-blockers. Content of ESBAR in serum (based on titers its dilution) depends on the presence of somatic diseases ( it was reduced at coronary heart disease, myocardial infarction, hypertension, and asthma in adults), of gender (content was higher in women) while at women depend on the stage of the reproductive process (during pregnancy, especially in the II trimester content of ESBAR increases, it is held high at birth and in early postnatal period) and on the presence of complications during pregnancy (increased at mild preeclampsia and at weakness of labor, but reduced at placental insufficiency, although it is not changed at the threat of premature labor. Possible mechanisms of action of ESBAR, physiological role of ESBAR, including ESBAR as a component of beta-adrenoreceptor inhibiting mechanism, as well as the prospect of the use of analogs ESBAR for the prevention of preterm labor, treatment of bronchial asthma, coronary heart disease, hypertension and congestive heart failure
Keywords: catecholamines, beta-adrenergic receptors, the endogenous sensitizer of beta-AR (ESBAR), smooth muscle, the myocardium, the erythrocytes, platelets, pregnancy, labor, beta-adrenoceptor inhibition mechanism
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Authors
Tsirkin Viktor I.
Kazan State Medical University
Russian Federation, 420012, Kazan, Butlerova str., 49
tsirkin@list.ru
Nozdrachyov Aleksandr D.
St. Petersburg State University
Russian Federation, 199034, St. Petersburg, Universitetskaya nab, 7-9
a.d.nozdrachev@mail.ru
Anisimov Konstantin Yu.
Ural State Medical University
Russian Federation, 620028, Yekaterinburg, Repin str. 3
kuanisimov@mail.ru
Sizov Elena N.
Vyatka Social and Economic Institute
Russian Federation, 610002, Kirov, Kazanskaya str. 91
Cizovahelena@mail.ru
Polezhaeva Tatyana V.
Institute of Physiology Komi Scientific Center Ural Branch of Russian Academy of Sciences Russian Federation, 167982, Syktyvkar, GSP-2, Pervomayskaya str. 50
ddic@yandex.ru
Khlybova Svetlana V.
Kirov State Medical Academy
Russian Federation, 610027, Kirov, Karl Marx str. 112
svekhlybova@yandex.ru
Morozova Marina A.
Vyatka State University
Russian Federation, 610000, Kirov, Moskovskaya str. 36
morozova_2406@mail.ru
Trukhin Andrey N.
Vyatka State University
Russian Federation, 610000, Kirov, Moscow str. 36
Trukhinandrey@rambler.ru
Korotaeva Julia V.
Kirov State Medical Academy
Russian Federation, 610027, Kirov, Karl Marx str. 112
Segecha-meinherz@mail.ru
Kunshin Alexey A.
Vyatka State University
Russian Federation, 610000, Kirov, Moscow str. 36
Tabyss@bk.ru
Received — 03.06.2016
For citation: Tsirkin V.I., Nozdrachyov A.D., Anisimov R.Yu., Sizova E.N., Polezhaeva T.V., Khlybova S.V., Morozova M.A., Trukhin A.N., Korotaeva Yu.V., Kunshin A.A. Mehanizmy polozhitel'noj i otricatel'noj moduljacii jeffektivnosti aktivacii adrenoreceptorov i drugih receptorov, associirovannyh s G-belkom (Obzor literatury). Soobshhenie 2. Jendogennyj sensibilizator β-adrenoreceptorov (Jesbar) kak polozhitel'nyj moduljator [Mechanisms of positive and negative modulation of the efficiency of the activation of adrenoceptors and other receptors associated with G-protein (Review). Communication 2. Endogenous sensitizer of Beta-Adrenergic receptors (Esbar) as a positive modulator]. Vestn. Ural. Med. Akad. Nauki. – Journal of Ural Medical Academic Science. 2016, no. 3, pp. 112–136. DOI: 10.22138/2500-0918-2016-15-3-112-136 [In Russ.]
